[This corrects the article DOI: 10.1371/journal.pone.0163524.].

OBJECTIVE Male fertility is affected by a variety of lifestyle habits that include tobacco use. A large population of Indian men is addicted to tobacco chewing. The objective of our study was to assess the relationship between tobacco chewing in these Indian men--who were part of an infertile couple--and their sperm characteristics. DESIGN Retrospective study. SETTING Private infertility cl...

Excess genetic material in the form of a small metacentric chromosome, often smaller than a member of the G group, has been reported in a number of cases (Ilberry, Lee, and Winn, 1961; Fr0land, Holst, and Terslev, 1963; Uchida et al, 1964; Taft, Dodge, and Atkins, 1965; Gustavson, Atkins, and Patricks, 1964, Crawfurd and Lele, 1965; Tamburro and Johnson, 1966; Gamstorp, Hfikansson, and Lagergre...

The high incidence of low sperm counts in young (European) men and evidence for declining sperm counts in recent decades mean that the environmental/lifestyle impact on spermatogenesis is an important health issue. This review assesses potential causes involving adverse effects on testis development in perinatal life (primarily effects on Sertoli cell number), which are probably irreversible, o...

Several studies showed that the genetic mutations in the folate-related enzyme genes might be associated with male infertility; however, the results were still inconsistent. We performed a meta-analysis with trial sequential analysis to investigate the associations between the MTHFR C677T, MTHFR A1298C, MTR A2756G, MTRR A66G mutations and the MTHFR haplotype with the risk of male infertility. O...

Currently, about 17% couples in industrialised countries seek medical advice for infertility (Cahill 2002). The definition of infertility is usually the failure to conceive after 1 year of unprotected intercourse (European Society 1996). Infertility can be primary, in women who have never conceived, or secondary, in women who have previously conceived. In the UK, about 10–20% of infertility cas...

Here we describe an improved method of separating sperm cells from lysed epithelial cells via acoustic cell trapping. In particular, we show that in the processing of samples with low numbers of sperm cells, addition of polymeric beads to the sample[1] allowed for better performance in terms of higher trapping efficiency versus our previous acoustic differential extraction (ADE) results[2]. We ...

OBJECTIVE Aproximately 10% of patients with non-obstructive azoospermia and 5% with non-obstructive severe oligozoospermia carry AZF region microdeletions (AZoospermic Factor) in the Y chromosome. The aim of this study is to analize the clinical and pathological findings in this group of patients and compare them with the previous evidence. MATERIAL AND METHODS Retrospective study of 11 patie...

Currently, about 17% couples in industrialised countries seek medical advice for infertility (Cahill 2002). The definition of infertility is usually the failure to conceive after 1 year of unprotected intercourse (European Society 1996). Infertility can be primary, in women who have never conceived, or secondary, in women who have previously conceived. In the UK, about 10–20% of infertility cas...