Norms have been extensively studied to coordinate multi-agent systems, and the literature has investigated two general approaches to norm synthesis: off-line (synthesising norms at design-time) and on-line (runtime synthesis). On-line synthesis is generally recognised to be appropriate for open systems, where aspects of the system remain unknown at design-time. In this paper we present LION , a...

taylor argues that procedural liberalism is not viable, or is insensitive to the conditions of social and political possibility, since it cannot justify the political furtherance of common goods. this is because the ontology and epistemology behind it disregard the “transcendental conditions” of human identity and the “dialogical” way of its formation. taylor’s own version of liberalism, on the...

There are several reasonable conceptions of liberalism. A liberal polity can survive a measure of disagreement over just what constitutes liberalism. In part, this is because of the way a liberal order makes possible a dynamic, heterogeneous civil society and how that, in turn, can supply participants with reasons to support a liberal political order. Despite the different conceptions of justic...

In previous papers we have mainly studied greedoids with the interval property. This paper exhibits 11 classes of greedoids whose members do not necessarily have the interval property. These non-interval greedoids are related to some fundamental algorithms and procedural principles like Gaussian elimination, blossom trees, series-parallel decomposition, ear decomposition, retracting and dismant...

An edge-coloring of a multigraph G with colors 1, . . . , t is called an interval t-coloring if all colors are used, and the colors of edges incident to any vertex of G are distinct and form an interval of integers. In this note, we show that all Eulerian multigraphs with an odd number of edges have no interval coloring. We also give some methods for constructing of interval non-edge-colorable ...

The aim of this study was to validate a simplified high-dosage, extended-interval netilmicin dosage regimen for infants. A total of 129 infants receiving 163 treatment courses of netilmicin (6 mg kg every 24 or 36 h depending on gestational age (GA), postnatal age and postmenstrual age) was analysed. Serum netilmicin concentrations were monitored before (Cmin), 30 min (C0.5h) after and 7.5 h (C...

Monosomy 21 is a rare human disease due to gene dosage errors disturbing a variety of physiological and morphological systems including brain, skeletal, immune and respiratory functions. Most of the human condition corresponds to partial or mosaic monosomy suggesting that Monosomy 21 may be lethal. In order to search for dosage-sensitive genes involved in the human pathology, we generated by ch...

The association of hemodialysis dosage with patient survival is controversial. Here, we tested the hypothesis that methods for survival analysis may influence conclusions regarding dialysis dosage and mortality. We analyzed all-cause mortality by proportional hazards and accelerated failure time regression models in a cohort of incident hemodialysis patients who were followed for 9 yr. Both mod...