spinal cord injury (sci) actuate to complex cellular and molecular interactions within the central nervous system in a heave to repair the initial tissue damage. the pathophysiology of acute spinal cord injury (sci) involves primary and secondary mechanisms. neuroinflammation is an important secondary injury process in sci. the local inflammatory microenvironment within the injured spinal cord ...

OBJECTIVES To develop the first high-resolution, multi-scale model of cervical non-invasive vagus nerve stimulation (nVNS) and to predict vagus fiber type activation, given clinically relevant rheobase thresholds. METHODS An MRI-derived Finite Element Method (FEM) model was developed to accurately simulate key macroscopic (e.g., skin, soft tissue, muscle) and mesoscopic (cervical enlargement,...

OBJECTIVE To evaluate the ability of a tissue-engineered nerve construct composed of a nerve guidance channel and neurally differentiated human adipose tissue-derived stem cells (hASCs) to enhance peripheral nerve regeneration in a rat sciatic nerve model. DESIGN A 13-mm sciatic nerve gap was bridged with silastic conduits in 64 athymic nude rats, and differentiated hASCs were implanted into ...

The use of nerve guidance conduits to repair peripheral nerve discontinuities has attracted much attention from the biomaterials community, with many resorbable and non-resorbable materials in clinical use. However, a material with ideal biocompatibility, sufficient mechanical properties (to match that of the regenerating nerve) coupled with a suitable degradation rate, has yet to be realized. ...

Introduction: Assessment of peripheral nerve disorders can be classified into clinical tests such nerve conduction test, performed to examine nerve functions and Neural Tissue Tension Tests designed to find out increased mechanosensitivity of the nerve being tested. Upper Limb Neural Tissue Tension Tests (ULTT) is a good tool for assessment of early affection of the neural tissue. Purpose of St...