نتایج جستجو برای: myelodysplastic syndromes
تعداد نتایج: 86513 فیلتر نتایج به سال:
Myelodysplastic syndromes (MDS) are a group of clonal hematologic disorders characterized by inefficient hematopoiesis, hypercellular bone marrow, dysplasia of blood cells and cytopenias. Most patients are diagnosed in their late 60s to early 70s. MDS is a risk factor for the development of acute myeloid leukemia which can occur in 10-15% of patients with MDS. A variety of pathophysiologic mech...
Myelodysplastic syndromes (MDS) represent a heterogeneous group of hematologic disorders characterized by ineffective hematopoiesis and an increased risk of developing acute myelogenous leukemia (AML). Accurate diagnosis of MDS can be difficult, and its classification requires evaluation of cytopenias, bone marrow morphology, blast percentage, and cytogenetics. These factors, as well as patient...
Background: The presence of somatic mutations in splicing factor 3b subunit 1 (SF3B1) in patients with Myelodysplastic syndromes with ring sideroblasts (MDS-RS) highlights the importance of the RNA-splicing machinery in MDS. We previously reported the presence of bone marrow (BM) RS in Sf3b1 heterozygous (Sf3b1) mice which are rarely found in mouse models of MDS. Sf3b1 mice were originally engi...
Myelodysplastic syndromes (MDS)are clinically characterized by morphological dysplasias of blood cells and cytopenias of variable combinations due to ineffective hematopoiesis (1). They often transform into acute myeloid leukemia (AML) as designated preleukemic syndromes. About 60% of cases with MDScarry a non-randomchromosomeabnormality such as -7, 7q-, -5, 5q-, 20qetc and/or complex abnormali...
Cancer Control 7 but this approach is unlikely to change the natural history of the disorder. Despite the recent approval of azacitidine, supportive care alone will remain an important treatment option for many patients with MDS. Supportive care consists of transfusions for symptomatic anemia or symptomatic thrombocytopenia, treatment of infections with antibiotics,and growth factors designed t...
Words: 686 Myelodysplastic syndromes (MDS) are a family of heterogeneous clonal hematological malignancies defined by peripheral cytopenias, a hypercellular or normal
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