In a small wood preserving industry spot samples were taken from contaminated surfaces at several places and tested for mutagenicity. The results suggest that the application of a wipe test can give a first indication of occupational exposure to mutagenic and carcinogenic substances, particularly when exposure occurs more from skin contact than from inhalation. One of the pesticide chemicals us...

Fifty-four polycyclic compounds, 29 of the cyclopenta[a]phenanthrene series, 11 chrysenes, and 14 benz[a]anthracenes, have been tested for mutagenicity by Ames's method, using Salmonella typhimurium TA100. Without exception all 37 carcinogens and a known initiator were mutagens. Of the 16 noncarcinogens 7 were mutagenic, but none of these has yet been tested for initiating, as opposed to carcin...

In this study, we investigate the potential of Moricandia arvensis methanol leaf extract (MeOHL) on calpain activity, melanin biosynthesis and DNA mutagenicity. Cytotoxic effect and measurement of reactive oxygen species (ROS) induced by lucigenin in colorectal cells (BE) were also determined. In addition the chemical analysis of the extract was also studied and the chemical profile illustrates...

A new method for assessment of molecular similarity based on original description of chemical structure is discussed. The accuracy of similarity assessment obtained with this method is compared with that of the results of four other approaches. The same evaluation set is used to predict: (a) boiling point of 139 hydrocarbons and (b) mutagenicity of 15 nitrosamines. The results show that the pro...

TBHQ has already been evaluated by the former Scientific Committee on Food (SCF) which concluded in 1987 that there was still a need for additional data. The SCF requested an adequate carcinogenicity study and an in vivo mutagenicity study of germ cell effects. At that time, the SCF was of the opinion that TBHQ was not acceptable for use as an antioxidant to food and did not establish an accept...

Some derivatives ot' 9-aminoacridine (1) were synthesized, and their frameshift mutagenicity and DNA binding aMnity were studied. The introduction of a methyl group into the acridine ring of 1 reduced the mutagenic activity and the intercalative DNA binding aMnity, whjle {he introdu ¢ tion of chlorine increased them. Halogenated derivatSyes f 1 showed higher toxicity against Saintonella mphiinu...