OBJECTIVES/HYPOTHESIS Evaluate presentation, management, and clinical outcomes of patients with temporal bone Langerhans cell histiocytosis (LCH). STUDY DESIGN Retrospective chart review. METHODS Reviewed all patients with temporal bone LCH at a tertiary academic referral center between 1978 and 2014. Presentation, disease course, intervention, and clinical outcomes were analyzed. RESULTS...

Cutaneous manifestations of COVID-19-SARS-CoV-2-are common and varied. Morbilliform, vesicular, urticarial eruptions may be nonspecific initial features the disease. Chilblainlike lesions on fingers or toes typically occur as part a resolution phase, signifying milder course, whereas livedoid retiform purpura are associated with coaguloapthy more severe Additionally, Kawasaki-like multisystem i...

SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) emerged in China exponentially and is recognized as a multisystem disease that gradually elevates markers associated with iron metabolism the infection becomes more intense, becoming critical factor investigation of prognosis. We review latest scientific findings on behavior ferritin pathophysiology laboratory COVID-19 (Coronavirus Di...

Neurofibromatosis type 1 is a hereditary disease that has multisystem character of organism damage, wide variability clinical manifestations, up to the almost complete absence typical symptoms. Phenotypic their expressiveness and heaviness can be varied even among members same family with identical mutations. One possible manifestations this pathology pheochromocytoma, development which associa...

Advances in genetics and pathology have supported the idea of a continuum between frontotemporal dementia (FTD) and motor neurone disease (MND), which is strengthened by the discovery of the trans-activating responsive (Tar) sequence DNA binding protein (TDP-43) as a key component in the underlying pathology of FTD, FTD-MND and sporadic and familial MND patients. MND is a multisystem disorder a...

Behcet's disease is a multisystem disease characterized by recurrent oral and genital ulcers, relapsing uveitis, mucocutaneous, articular, gastrointestinal, neurologic, and vascular manifestations. Rheumatologic manifestations may also occur in Behcet's disease, and arthritis and arthralgia are the most common musculoskeletal findings followed by enthesopathy, avascular necrosis, myalgia, and m...