A simple technique for the synthesis of optical pulse sequences is described, where the input laser spectrum is viewed as a superposition of independent but interlaced combs assigned to different sub-pulses. The devised concept enables intuitive programming of complex multi-pulse waveforms via one-dimensional phase-only shaping. Using this approach, we perform self-referenced cross-correlation ...

In the Indian Mcdical Gazette of January 1929, we reported seven cases of diaphysial aclasis (multiple exostosis) in Indians, including four cases from one family. The present case showed an even more marked family history, there being some 10 cases amongst 26 close relatives. Hasan Mohamed Khan, aged 45, was admitted into King George's Medical College Hospital, Lucknow, in January 1929, for ln...

We investigate the macroscopic diffusion of carriers in the multiple-trapping (MT) regime, in relation with electron transport in nanoscaled heterogeneous systems, and we describe the differences, as well as the similarities, between MT and the continuous-time random walk (CTRW). Diffusion of free carriers in MT can be expressed as a generalized continuity equation based on fractional time deri...

Maastricht University, School for Public Health and Primary Care (CAPHRI), Department of General Practice, 6200 MD Maastricht, Netherlands Department of Internal Medicine and Gastroenterology, Atrium Medisch Centrum Parkstad, 6401 CX Heerlen, Netherlands Department of Laboratory Medicine, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, Netherlands Correspondence to: M A van Bokhov...

Hereditary hemochromatosis is definitively diagnosed based on liver biopsy findings.

Colorectal tumours constitute an excellent system to study carcinogenesis and the molecular events implicated in the development of cancer. Attending to the way it is transmitted, colorectal cancer may appear in one of three forms: sporadic, familial, and hereditary. The sporadic form is most common and has no familial or hereditary associated factor thus far, while familial and hereditary form...

Hamartomas represent localized overgrowth of cells in the parts which are normally associated with polyps, ie. mesenhimal, stromal, endodermal and ectodermal elements. Hamartomatous polyposis syndromes carry a significant risk of developing dysplasia, adenomas, gastrointestinal carcinomas, and pancreatic carcinomas. These syndromes may be classified on the basis of whether they represent heredi...

Recent progress in the treatment of multiple sclerosis (MS) is remarkable, and the introduction of new therapies is yielding improvements in the management of MS. Furthermore, clinical trials with many different types of agents, especially selected monoclonal antibodies, have been undertaken or are ongoing, and some of the agents involved will probably be available as treatments for MS in the n...

Multiple sclerosis associated with neurofibromatosis type 1 (NF1) is a very rare event. Seven patients with multiple sclerosis and NF1 are described in the literature, and all were reported to have the primary progressive form of multiple sclerosis. Three new patients with NF1 that developed multiple sclerosis are described and it is shown that the range of multiple sclerosis associated with NF...