نتایج جستجو برای: msi

تعداد نتایج: 3019  

2015
Chun Gan Clare Love Victoria Beshay Finlay Macrae Stephen Fox Paul Waring Graham Taylor

Microsatellite instability (MSI) is a useful marker for risk assessment, prediction of chemotherapy responsiveness and prognosis in patients with colorectal cancer. Here, we describe a next generation sequencing approach for MSI testing using the MiSeq platform. Different from other MSI capturing strategies that are based on targeted gene capture, we utilize "deep resequencing", where we focus ...

Journal: :The American journal of surgical pathology 2011
Alton B Farris Elizabeth G Demicco Long Phe Le Karin E Finberg Julie Miller Rajni Mandal Junya Fukuoka Cynthia Cohen Henning A Gaissert Lawrence R Zukerberg Gregory Y Lauwers A John Iafrate Mari Mino-Kenudson

Microsatellite instability (MSI) has been reported in various tumors, with colon cancer as the prototype. However, little is known about MSI in Barrett esophagus (BE)-associated adenocarcinoma. Thus, the aim of this study was to compare the clinicopathologic and molecular features of BE-associated adenocarcinomas with and without MSI. The study cohort consisted of 76 patients with BE-associated...

Journal: :Scandinavian journal of gastroenterology 2002
T Løvig G I Meling C B Diep L Thorstensen S Norheim Andersen R A Lothe T O Rognum

BACKGROUND Adenomatous polyposis coli (APC) and beta-catenin (encoded by CTNNB1) are important components in the WNT signalling pathway, a pathway altered in nearly all colorectal tumours. Conflicting results are reported on whether APC mutations are less common in tumours with a high degree of microsatellite instability (MSI-H) than in microsatellite stable (MSS) ones, and whether mutations in...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2003
Catherine Shannon Judy Kirk Rebecca Barnetson Justin Evans Margaret Schnitzler Michael Quinn Neville Hacker Alex Crandon Paul Harnett

PURPOSE Families with hereditary nonpolyposis colorectal cancer (HNPCC) have an increased lifetime risk of endometrial (40%) and ovarian (10%) carcinomas. Endometrial and ovarian carcinomas from members of these families frequently display a mutator phenotype as manifest by high levels of microsatellite instability (MSI-H). Microsatellite instability (MSI) occurs in 17-32% of sporadic endometri...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2009
Krishan Kumar Hassan Brim Francis Giardiello Duane T Smoot Mehdi Nouraie Edward L Lee Hassan Ashktorab

PURPOSE Colorectal cancer develops through genetic, epigenetic, and environmental events that result in uncontrolled cell proliferation. Colorectal cancer incidence and mortality is higher in African Americans (AA) than in the general population. Here, we carried out a molecular analysis of sporadic colorectal cancer tumors from AAs to investigate possible explanations for the observed disparit...

Journal: :Cancer prevention research 2012
Angela N Bartley Rajyalakshmi Luthra Devki S Saraiya Diana L Urbauer Russell R Broaddus

Tissue-based microsatellite instability (MSI) analysis and immunohistochemistry for DNA mismatch repair proteins are accepted screening tools to evaluate patients with cancer for Lynch syndrome. These laboratory analyses are thus important tools in cancer prevention. Quality assurance review was conducted to identify test discordances and problems. These results were then analyzed in conjunctio...

2018
Sanghee Kang Younghyun Na Sung Yup Joung Sun Il Lee Sang Cheul Oh Byung Wook Min

The colorectal cancer (CRC) patients with microsatellite instability (MSI) have distinct clinicopathological characteristics consisting of factors predicting positive and negative outcomes, such as a high lymph node harvest and poor differentiation. In this study, we measured the value of MSI as a prognostic factor after controlling for these discrepant factors. A total of 603 patients who unde...

Journal: :The European respiratory journal 2008
D Makris N Tzanakis A Damianaki E Ntaoukakis E Neofytou M Zervou N M Siafakas E G Tzortzaki

Increased frequency of microsatellite DNA instability (MSI) has been detected in the sputum of chronic obstructive pulmonary disease (COPD) patients. The aim of the present study was to investigate the relationship between MSI in sputum cells and exacerbation frequency, which is an important parameter in the clinical course of the disease. Induced sputum samples and peripheral blood obtained fr...

2015
Elaine I. Lin Li-Hui Tseng Christopher D. Gocke Stacy Reil Dung T. Le Nilofer S. Azad James R. Eshleman

Microsatellite instability (MSI) is caused by defective mismatch repair in 15-20% of colorectal cancers (CRCs). Higher mutation loads in tumors with mismatch repair deficiency can predict response to pembrolizumab, an anti-programmed death 1 (PD-1) immune checkpoint inhibitor. We analyzed the mutations in 113 CRCs without MSI (MSS) and 29 CRCs with MSI-High (MSI-H) using the 50-gene AmpliSeq ca...

Journal: :Archives of surgery 2009
Giovanni Corso Corrado Pedrazzani Daniele Marrelli Valeria Pascale Enrico Pinto Franco Roviello

HYPOTHESIS Microsatellite instability (MSI) correlates with clinicopathologic characteristics and long-term prognosis in patients having gastric carcinoma. DESIGN Analysis of prospectively collected data and biologic material. SETTING Tertiary University Hospital, Policlinico "Le Scotte," Siena, Italy. PATIENTS Two hundred fifty patients with gastric carcinoma. MAIN OUTCOME MEASURES Fiv...

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