Background/Purpose: Phimosis, owing to the presence of a preputial fibrotic ring, is surgically treated in 1% of children. During the last decade, however, topical steroid treatment has been proposed for phimosis. Methods: We present a double-blind study comparing 0.1% mometasone furoate topical cream vs moisturizing cream (placebo) for the treatment of phimosis. Children aged from 2 to 13 year...

We wish to respond to a recent discussion of systemic bioavailability of inhaled corticosteroids that appeared as a letter to the editor [1]. The authors contend that an estimate of the true systemic bioavailability of inhaled mometasone furoate (MF) cannot be made based on incomplete data and an insensitive assay, and that comparisons with other inhaled steroids certainly cannot be made. The a...

BACKGROUND Allergic rhinitis, especially when persistent (PER) and associated with asthma heavily impairs patients' quality of life (QoL). OBJECTIVE This study assessed the effect of mometasone furoate nasal spray (MFNS) on the QoL of patients with PER and asthma, using the Rhinasthma questionnaire (EUDRACT n. 2007-004683-45). METHODS Patients with moderate/severe PER and intermittent asthm...

A 69-year-old non-atopic woman presented with eczematous lesions on her legs, trunk, and upper limbs. The history revealed that, one month before the development of the eczema, she had been applying an emollient cream to her legs (BioEulen Pediatric Cream, Aboca, Sansepolcro, Italy) based on natural ingredients to treat a moderate xerosis. She was treated with topical corticosteroids (mometason...

OBJECTIVES To investigate the effect of rhinophototherapy with medical therapy on quality of life in persistent allergic rhinitis. METHODS A prospective, randomized study was being performed between December 2009 and March 2010. The study included 65 patients with persistent allergic rhinitis. The diagnosis was confirmed with positive skin tests. All of the patients had house dust mite allerg...

BACKGROUND/PURPOSE Phimosis, owing to the presence of a preputial fibrotic ring, is surgically treated in 1% of children. During the last decade, however, topical steroid treatment has been proposed for phimosis. METHODS We present a double-blind study comparing 0.1% mometasone furoate topical cream vs moisturizing cream (placebo) for the treatment of phimosis. Children aged from 2 to 13 year...

BACKGROUND Although combined oral and nasal steroid therapy is widely used in nasal polyposis, a subset of patients show an unfavorable therapeutic outcome. This study aimed to evaluate whether oral prednisolone produces any additive effects on subsequent nasal steroid therapy and to evaluate if any clinical variables can predict therapeutic outcome. METHODS Using a 3:2 randomization ratio, ...

OBJECTIVE Intranasal steroids (INS) are firmly established as the therapy for choice for allergic rhinitis, but their role in vasomotor rhinitis (VMR) is not fully characterized. This review examines the potential mechanisms of action and reported efficacy of INS in patients with VMR. RESULTS INS, through intracellular activation of the glucocorticoid receptor, down-regulate the recruitment a...

Background: Pharmacokinetic properties, dosing regimen, and potency at the site of action are among the factors that influence activity of a corticosteroid. The potency of a corticosteroid at the site of action is determined significantly by its affinity to the glucocorticoid receptor. Recent literature on topical corticosteroids reveals an increasing emphasis on comparative relative receptor a...

This systematic review aims first to summarize the previous areas of application of computational fluid dynamics (CFD) and then to demonstrate that CFD is also a suitable instrument for generating three-dimensional images that depict drug effects on nasal mucosa. Special emphasis is placed on the three-dimensional visualization of the antiobstructive effect of nasal steroids and antihistamines ...