Migraine is a primary disorder of the brain with peripheral consequences. The prevalence of migraine is as high as 18% in the general populations. The association between migraine and stroke has been well documented in many case-control and cohort studies. This association has been stronger in patients with migraine with aura compared to migraine without aura and dependent on sex, age, frequenc...

Migraine without aura is frequently reported in female patients with irritable bowel syndrome (IBS), but knowledge about the relationship between these two conditions is still lacking. This study was aimed to explore the particularities of migraine without aura in young female patients with IBS in order to establish a possible link between them. From a cohort of young female patients hospitaliz...

Migraine is a serious health problem which impair quality of life. It is the second most common primary headache that affects approximately more than %10 people in general population. Migraine pathophysiology is still unclear. Increasing results of studies suggest to migraine pathophysiology is related with primary neuronal mechanisms. Migraine pain starts in which region of brain and what brai...

See related article, pages 2438–2445. Migraine with aura has been consistently associated with increased risk of ischemic stroke.1–3 Most studies suggest that this association is particularly strong for younger women. Although several potential biological mechanisms have been proposed to explain the migraine-stroke association, the precise mechanisms remain unknown. Because migraine is particul...

Atypical features of hemicrania continua (HC), including both visual aura and side shifting, have been reported previously. However, auras and variable unilaterality have never been reported together in HC. We report two patients with side-shifting HC with aura. These patients' symptoms are unilateral headaches, visual aura, autonomic features, throbbing pain, nausea and photo/phonophobia. One ...

FHM3 is a rare subtype of familial hemiplegic migraine (FHM) caused by mutations in the neuronal sodium channel gene SCN1A (1). Only five FHM3 mutations have been described in a few families since the identification of SCN1A as the third FHM gene in 2005 (1–4). In the present issue of Cephalalgia, Weller et al. (5) report the identification of two novel SCN1A FHM3 mutations in two families with...

In 1944, Leão described cortical spreading depression, the phenomenon now widely believed to underlie what some persons with headache perceive as “aura.” Aura is a somewhat misleading term because it can occur before a migraine, during or after a migraine, or occur without any associated headache. It can also occur with many other types of headache, but in clinical practice it is usually in ass...

 Introduction: Migraine is a refer pain which is common in adults and children. Migraine and its frequently limits the daily life activities. Since medical students are subjected to stresses regarding lots of tests and the implicit responsibility to the courses, the purpose of the present study carried out to evaluate the prevalence of migraine among medical students in Zahedan University. Meth...

Stroke is one of the main causes of death and disability worldwide, and only in Sweden approximately 25 000 individuals suffer from stroke each year. This thesis focuses on two common conditions; migraine and patent foramen ovale (PFO) and their role in stroke. Migraine is a common primary headache disorder, affecting approximately 11-13 % of the population with a 3:1 female preponderance. One ...

" What do cortical thickness increases mean and what are the potential implications? " Migraine is a very widespread and debili-tating disease and according to the WHO, one of the most common disorders of the nervous system. Prevalence studies estimate that migraine affects 15–25% of women and 6–8% of men [1–4], and over 2.5 million people in North America have migraine at least one day per wee...