نتایج جستجو برای: micronucleus

تعداد نتایج: 2330  

Journal: :Journal of cell science 1975
F P Doerder L E Debault

Fluorescence cytophotometry was used to study nuclear DNA content and synthesis patterns during meiosis, fertilization and macronuclear development in the ciliated protozoon, Tetrahymena pyriformis, syngen 1. It was found that cells entered conjugation with a G1 (45C) macronucleus and a G2 (4C) micronucleus. During meiosis the micronucleus was reduced to 4 haploid nuclei, each with a 1C amount ...

Journal: :Mutagenesis 2011
Azeddine Elhajouji Magdalena Lukamowicz Zoryana Cammerer Micheline Kirsch-Volders

The concept of thresholds in genotoxicity has been open for debate in the last decades. The micronucleus (MN) test contributed to a large extent in understanding the dose-response relationship for aneugens and clastogens. The threshold concept for aneuploidy is well accepted by the scientific community based on the data and for mechanistic reasons. The concept of threshold for clastogens is sti...

2009
Toni P. Galindo Lília M. Moreira

The micronucleus and nuclear abnormalities assays have been used increasingly to evaluate genotoxicity of many compounds in polluted aquatic ecossystems. The aim of this study is to verify the efficiency of the micronucleus assay and nuclear abnormality assay in field and laboratory work, when using erythrocytes of the tropical marine fish Bathygobius soporator as genotoxicity biomarkers. Gill ...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2004
Yu Wen Cheng Wen Wha Lee Ching Hao Li Chen Chen Lee Jaw Jou Kang

We studied the genotoxic potency of motorcycle exhaust particles (MEP) by using a bacterial reversion assay and chromosome aberration and micronucleus tests. In the bacterial reversion assay (Ames test), MEP concentration-dependently increased TA98, TA100, and TA102 revertants in the presence of metabolic-activating enzymes. In the chromosome aberration test, MEP concentration-dependently incre...

1999
Lila Kari Jarkko Kari Laura F. Landweber

We prove that a reversible model for the guided homologous recom-binations that take place during gene rearrangement in ciliates has the computational power of a Turing machine, the accepted formal model of computation. This indicates that, in principle, these unicellular organisms may have the capacity to perform any computation carried out by an electronic computer. 1 Gene unscrambling as com...

Journal: :Genetics and molecular research : GMR 2010
E L Maistro S F Mota E B Lima B M Bernardes F C Goulart

Rosmarinus officinalis (rosemary) oil is widely used by the cosmetic, food, and pharmaceutical industries as a fragrance component of soaps, creams, lotions, and perfumes. Although it is popular, potential harmful side-effects of the oil have been described. We investigated the genotoxic and mutagenic potential of essential oil of R. officinalis in rodents, using comet, micronucleus and chromos...

Journal: :Radiation research 1995
K G Hofer S P Bao

Chinese hamster ovary cells were pulse-labeled with 125I-iododeoxyuridine during early S phase, and cell samples were harvested 30 min or 5 h after labeling. The samples were frozen (with or without 25 mM cysteamine) and stored at -196 degrees C for accumulation of 125I decays. X-ray control experiments were performed at 37 degrees C and -196 degrees C. Aliquots of cells were plated for evaluat...

Journal: :Eukaryotic cell 2004
Jeffrey S Fillingham Ronald E Pearlman

Extensive programmed DNA rearrangements occur during the development of the somatic macronucleus from the germ line micronucleus in the sexual cycle of the ciliated protozoan Tetrahymena thermophila. Using an in vivo processing assay, we analyzed the role of micronucleus-limited DNA during the programmed deletion of mse2.9, an internal eliminated sequence (IES). We identified a 200-bp region wi...

Journal: :Toxicology and industrial health 2016
Amin Karamian Mohammad Shokrzadeh Amirhossein Ahmadi

The protection afforded by melatonin (MLT) against diazinon (DZN)-induced micronucleus formation, an index of DNA damage, in human blood lymphocytes was investigated. Whole blood samples were collected from five volunteers and were incubated with MLT at different concentrations (100, 200, 300, and 400 µM final concentration) for 1 h. The samples were then incubated with 750 µM DZN for 1 h. Subs...

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