One of the most common characteristics of cancer cells is genomic instability. Recent research has revealed that G2/M-phase checkpoint adaptation-entering mitosis with damaged DNA-contributes to genomic changes in experimental models. When cancer cells are treated with pharmacological concentrations of genotoxic agents, they undergo checkpoint adaptation; however, a small number of cells are ab...

This in vitro study evaluated the biocompatibility and abrasivity of whitening conventional toothpastes. Samples (non-whitening) - Edel White Infant (EWI) toothpastes Whitening (EWW), CAREFORTE (EWC), Colgate Total 12 Ò Professional (C), Oral-B (OB) were dissolved culture medium (0.2 g sample weight per mL). Human gingival fibroblasts (hGF) placed contact with different dilutions media that had...

The present study was investigated to evaluate the protective and therapeutic role of Moringa oleifera leaf extract (MOLE) against CCL4-induced toxicity in rats . Male Albino rats of eleven groups (eight animals each) were used in this study : negative control ; control of olive oil ; positive control received CCL4 in olive oil for 12 weeks ; groups 4-7 received CCl4 in olive oil + MOLE at dose...

background: a radioprotective effect of amifostine as well as its ability to modulate the level of spontaneous and gamma-irradiation-induced genetic changes on human peripheral blood lymphocytes has been investigated . amifostine, known as a potent radical scavenger, has been introduced as the most effective radioprotector, yet it is not completely approved for the clinical use. however, furthe...

objective: micronuclei are induced in cells by a variety of substances, like uv radiation, infrared rays, x-radiations, and chemicals. among them tobacco- specific nitrosamines have been reported to be potent mutagenic agents which are thought to be responsible for the induction of chromosomal aberrations resulting in production of micronuclei. the main aim of our study is to compare mn frequen...

background : we intend to study the inhibitory effect of sulfur compound in ramsar hot spring mineral on tumor-genesis ability of high natural background radiation. objective : the radioprotective effect of sulfur compounds was previously shown on radiation-induced chromosomal aberration, micronuclei in mouse bone marrow cells and human peripheral lymphocyte. ramsar is known for having the high...