UNLABELLED Brown RE, Bruce SH, Jakobi JM. Is the ability to maximally activate the dorsiflexors in men and women affected by indwelling electromyography needles? OBJECTIVES To determine whether maximal force is similar between conditions with and without a microelectrode, and to evaluate potential sex differences when using invasive procedures. DESIGN Crossover trial. SETTING University l...

In the past, doctors usually treated disorders of the nervous system by substitution instead of correction, including wheelchairs for walking, braille for text, and sign language for speech. However, as our understanding of the nervous system increases, so does our ability to treat its disorders with neural prostheses that directly stimulate the nervous system. Cochlear implants are one example...

This work aims to optimize Plasma-Enhanced Chemical Vapour Deposition (PECVD) amorphous hydrogenated silicon carbide (a-SiC:H) as a conformal passivation layer for invasive microelectrode array (MEA) neural interface applications. By carefully tuning the PECVD deposition parameters, composition, structure, electrical, and mechanical properties of films can be optimized high resistivity, low str...

One of the critical requirements of the emerging class of neural prosthetic devices is to maintain good quality neural recordings over long time periods. We report here a novel MEMS (Micro Electro Mechanical Systems) based technology that can move microelectrodes in the event of deterioration in neural signal to sample a new set of neurons. Microscale electro-thermal actuators are used to contr...

The vast majority of centers use electrophysiological mapping techniques to finalize target selection during the implantation of deep brain stimulation (DBS) leads for the treatment of Parkinson's disease and tremor. This review discusses the techniques used for physiological mapping and addresses the questions of how various mapping strategies modify target selection and outcome following subt...

BACKGROUND Reducing cost and time is the major concern in clinical diagnostics, particularly in molecular diagnostics. Miniaturization technologies have been recognized as promising solutions to provide low-cost microchips for diagnostics. With the recent advancement in nanotechnologies, it is possible to further improve detection sensitivity and simplify sample preparation by incorporating nan...

Exploration of the cytoplasm of the giant esophageal cell of Ascaris with a recording microelectrode shows the existence of shallow spaces where the microelectrode tip becomes extracellular in spite of being in the interior of the cell. When the microelectrode penetrates into these spaces from the cytoplasm, the resting potential shifts to a different level or entirely disappears. At the same t...

In acute experiments eight 5- to 24-wire-microelectrode arrays were inserted into the common peroneal nerve of the rat, to investigate whether the electrodes could selectively stimulate motor units of the extensor digitorum longus (EDL) muscle. Twitch-force-recruitment curves were measured from the EDL for each array electrode. The curves were plotted on a double-logarithmic scale and parameter...

In this paper, we report a new electroanalytical technique we call snapshot voltammetry. This method combines the properties of bipolar electrodes with electrogenerated chemiluminescence (ECL) to provide a means for recording optical voltammograms in a single micrograph. In essence, the information in a snapshot voltammogram is contained in the spatial domain rather than in the time domain, whi...

The use of pH-sensitive microelectrodes for the determination of ttubular pH in amplhibian neplirons dates from the early days of kidney micropuncture. Soon after this metlhodology was introduced by Riclhards and hiis coworkers, MIontgomery and Pierce(1,2) publislhed their papers on the (letermination of tubular pH in Necturus and in frogs by means of a quinlhydrone microelectrode. In this micr...