Background: The purpose of this study was to evaluate the risk peri-prosthetic fracture constructs made with cephalomedullary (CM) long and short nails. nails were titanium alloy (Ti-6Al-4V) stainless steel (SS 316L). Methods: Biomechanical evaluation CM nail carried out regard post-primary healing determine peri-implant/peri-prosthetic fractures. Therefore, research comprised of, non-fractured...

The effect of protein binding on kidney function has been studied by investigating the renal accumulation and secretion of the hippurate analogue 2-methylbenzoylglycine in the isolated perfused rat kidney in the absence and presence of bovine serum albumin (BSA). Experiments were performed with either 2.5% pluronic or a combination of 2.2% pluronic and 2% BSA as oncotic agents; a wide concentra...

The reactivity of tyrosinase adsorbed on nanogold bound with 4,4'-bis(methanethiol)biphenyl monolayer self-assembled on a gold disk with catechol in a dipolar aprotic solvent, acetonitrile (AN), was studied by cyclic voltammetric and amperometric methods. Tyrosinase exhibited characteristics of a Michaelis-Menten kinetic mechanism. The tyrosinase attached to the nanogold continued to react with...

Malakoplakia, first described by Michaelis and Gutmann in 1902 [1], occurs mainly in the genitourinary tract (60% of cases), and less frequently in the gastrointestinal tract (10% of cases) [2]. Although the pathogenesis of malakoplakia is not completely understood, the disease may be considered the result of an impairment of the mononuclear phagocyte and immunoregulatory effector system [3]. T...

We present a simple model which extends the Michaelis-Menten mechanism by incorporating a continuous protein conformational change in enzymatic catalysis. This model can represent a quantitative version for "rack" or "induced fit" mechanisms. In the steady-state it leads to an equation of the Michaelis-Menten form, but with the catalytic step at the active site showing strong dependence on solv...

It is well known that Michaelis–Menten kinetics is suitable for the response function in chemical reaction, when the reaction rate does not increase indefinitely when an excess of resource is available. However, the existing models for insulin therapies assume that the response function of insulin clearance is proportional to the insulin concentration. In this paper, we propose a new model for ...

We consider the basic SIR epidemiological model with the Michaelis-Menten formulation of the contact rate. From the study of Michaelis-Menten basic enzymatic reaction, we design two types of Nonstandard Finite Difference (NSFD) schemes for the SIR model: Exact-related schemes based on the Lambert W function and schemes obtained by using Mickens’s rules of more complex denominator functions for ...

For enzymatic progress curves conforming to the Michaelis–Menten mechanism (E + S ES → E + P) under the experimental conditions where the substrate concentration is at least several times smaller than the Michaelis constant, the minimal fitting model cast as a system of numerically integrated differential equations is the simple ‘hit-and-run’ mechanism, E + S → E + P. The best-fit value of sing...

The action of a biosensor containing non Michaelis-Menten enzyme was modeled at mixed enzyme kinetics and external diffusion limitation in the case of substrate inhibition. The calculations show that at the electrode surface multi steady-state concentrations of substrate may be generated if diffusion module is much larger than 1 and the substrate bulk concentration is much bigger than Michaelis...

The kinetics of a very large NAD-dependent glutamate dehydrogenase from Janthinobacterium lividum showed positive cooperativity toward alpha-ketoglutarate and NADH, and the Michaelis-Menten type toward ammonium chloride in the absence of the catalytic activator, L-aspartate. An increase in the maximum activity accompanied the decrease in the S(0.5) values for alpha-ketoglutarate and NADH with t...