Objective(s): The objective of this study was to investigate the hepatoprotective effect of licochalcone B (LCB) in a mice model of carbon tetrachloride (CCl4)-induced liver toxicity. Materials and Methods: Hepatotoxicity was induced in mice by a single subcutaneous injection (SC) of CCl4. The LCB was administered orally once a day for seven days (PO) as pretreatment at three doses of 1, 5, and...

Background & Aim: Cutaneous infection caused by protozoa the genus Leishmania are a major worldwide health problem, with high endemicity in developing countries including Middle East, Africa and Latin America. In the absence of a vaccine, there is an urgent need for effective drugs to replace and supplement those in current use. Experimental: In this study, the in vivo effica...

Brown adipocytes mainly utilize glucose and fatty acids to produce energy, which play key roles in thermogenesis. Furthermore, brown also other substrates, such as amino acids, for energy expenditure various conditions. Here, we report the new physiological of proton-coupled acid transporters, SLC36A2 SLC36A3, on global metabolism. The relative mRNA expression levels both Slc36a2 Slc36a3 were a...

Background: Sepsis is a systemic inflammatory disease in response to the pathogens that leads to vital organ failures the failure of vital organs. Appropriate animal models should be developed to measure the effectiveness of therapeutic methods. Cecal Ligation and Puncture (CLP) is the most widely used methods of creating the sepsis model. Some variables interfere in the creation of the CLP mod...

objective(s): the objective of this study was to investigate the hepatoprotective effect of licochalcone b (lcb) in a mice model of carbon tetrachloride (ccl4)-induced liver toxicity. materials and methods: hepatotoxicity was induced in mice by a single subcutaneous injection (sc) of ccl4. the lcb was administered orally once a day for seven days (po) as pretreatment at three doses of 1, 5, and...

Abstract The protozoan parasite Plasmodium infection can cause malaria in both humans and animals. There are reports about the resistance to certain antimalarial medications. Therefore, searching for alternative medicine, such as herbal remedies, is important. This study focused on pathophysiology of livers mice infected intraperitoneally with berghei efficacy ethanol extract from breadfruit pe...

Background: The natural origin of medicinal plants does not guarantee their safety, as there are no sufficient studies on the efficacy, and toxicity to support benefit claims. Objectives: This study aimed at investigating oral acute Adansonia digitata L. (A. digitata) fruit shell extract in mice. Methods: maceration method was employed for extraction A. using methanol. then screened its phytoch...

Abstract Metastases are the primary cause of cancer mortality, and different sites metastasis associated with prognostic outcomes. In particular, liver metastases poor overall survival increased disease progression. It is known that suppress systemic antitumor immunity to limit immunotherapy efficacy on tumors through hepatic siphoning deletion CD8 +T cells, induction T regulatory depletion den...

Molecular effects of sterol-enriched wheat bran oil (eWBA) on lipid metabolism, inflammatory markers, and liver proteome associated with nonalcoholic/metabolic-related fatty disease (MAFLD) are not completely known. In this study, dietary eWBA intervention was used to investigate its effect in ameliorating injury high fat diet (HFC)-fed C57BL/6 mice. Specifically, we examined eWBA’s (i) differe...

Abiraterone acetate for metastatic castration-resistant prostate cancer is an acetylated prodrug to be hydrolyzed abiraterone. known by pancreatic cholesterol esterase secreted into the intestinal lumen. This study aimed investigate possibility that arylacetamide deacetylase (AADAC) expressed in enterocytes contributes hydrolysis of abiraterone based on its substrate preference. hydrolase activ...