The present study investigated to know whether the pomegranate polyphenol punicalagin (PU) can ameliorate oxidative stress and pathological alterations induced by a calorie rich diet comprised of fat fructose. Male Swiss albino mice were fed normal pellet (Control) or high fat-high fructose (HFFD) for 60 days. PU (30 mg/kg bw) was administered orally last 15 days both dietary groups. Measuremen...

Abstract Cerebral malaria (CM) is a severe complication of P. falciparum infection and leading cause death, globally. Plasmodium berghei ANKA (PbA) C57BL/6 mice serves as murine model CM called experimental cerebral (ECM) due to the neurological neuropathological features that simulate human CM. A putative mechanism disease in requires CD8 T cell infiltration into brain blood-brain barrier disr...

Background: Air fresheners are products with fragrances used to mask unpleasant odor in the environment. However, air fresheners contain diverse chemical substances that pose health challenges to the users; hence are of public health significance. Although previous studies have shown that air fresheners affect the lungs, liver and reproductive organs, the neurobehavioral effects of these agent...

Background: Radioprotective efficacy of Prunus avium fruit extract (PAE) rich in vitamin A, C, E and anthocyanin was studied against radiation induced biochemical alterations in mice brain. Materials and Methods: In-vitro assays were performed with PAE for its antioxidant studies thereafter for in-vivo study, Swiss albino mice were divided into five groups. Group 1 (control) normal mice. Group ...

Sodium valproate and tomato extract have been studied in different experimental models of epilepsy individually. The aim of the present study was to evaluate the effect of lycopene on the antiepileptic effects of sodium valproate against pentylenetetrazol-induced kindling in mice. Swiss albino mice of either sex were randomly divided into 5 groups, with each group containing 8 mice. These group...

Abstract [ 99m Tc] fonturacetam hydrazide was radiosynthesized to assess neuropsychiatric disorders by targeting the brain. The nootropic drug labeled with technetium-99m, and factors affecting labeling yield were studied. At optimum conditions, radiocomplex obtained at a high radiochemical (98.9%) stable in saline for up 36 h serum more than 24 h. Labeled characterized assessed silico. Biodist...

Introduction Licorice could exhibit beneficial effect in the management of insomnia by regulating key modulators such as GABA and serotonin, we therefore aimed to study potentail hypnotic licorice extract, glycyrrhizin (GCZ), on underlying mechanisms. Material methods Mice were randomly grouped a Control group, GCZ (low) (high) group DZP with 8 mice each group. Sleep latency, sleep duration loc...

Beta-Ca2+/calmodulin-dependent protein kinase II (βCaMKII) is known as a powerful regulator of lateral habenula neuron function and key molecular determinant depression. βCaMKII also abundant in the hippocampus, especially dentate gyrus (DG). However, whether DG involved emotional behaviors remains unknown. In this study, using βCaMKII-F90G transgenic mice, which overexpression restr...

DHIPC (2,4-dichloro-2´-hydroxyl-4´,6´-diisoprenyloxychalcone) is a new chalconecompound. In this study, its antidepressant-like activity of compound DHIPC was evaluated bythe forced swimming test and the tail suspension test in mice. The results showed that DHIPCsignificantly reduced the immobility time for 2 h after treatment through the oral administrationat dose of 10, 20, and 30 mg/kg in th...