نتایج جستجو برای: mck
تعداد نتایج: 210 فیلتر نتایج به سال:
OBJECTIVE A decrease in muscle protein turnover and therefore in muscle mass is a hallmark of aging. Because the circulating levels of the bone-derived hormone osteocalcin decline steeply during aging in mice, monkeys and humans we asked here whether this hormone might regulate muscle mass as mice age. METHODS We examined muscle mass and strength in mice lacking osteocalcin (Ocn-/-) or its re...
Mitochondrial dysfunction has been implicated in the pathogenesis of type 2 diabetes. Identifying novel regulators of mitochondrial bioenergetics will broaden our understanding of regulatory checkpoints that coordinate complex metabolic pathways. We previously showed that Nur77, an orphan nuclear receptor of the NR4A family, regulates the expression of genes linked to glucose utilization. Here ...
There is no effective treatment for the cardiomyopathy of the most common autosomal recessive ataxia, Friedreich's ataxia (FA). The identification of potentially toxic mitochondrial (MIT) iron (Fe) deposits in FA suggests that Fe plays a role in its pathogenesis. This study used the muscle creatine kinase conditional frataxin (Fxn) knockout (mutant) mouse model that reproduces the classical tra...
Comparing maps is an important issue in environmental research. Reasons for comparing maps may be: (i) the different socio-economic scenarios on which they are based, (ii) detection of temporal changes, (iii) calibration/validation of land-use models, (iv) hotspot detection, (v) their use in uncertainty analysis, and (vi) their origin in different methodologies/models. This report addresses the...
miRNAs have been widely investigated in terms of cell proliferation and differentiation. However, little is known about their effects on bird growth. Here we characterized the promoter of miR-206 in chicken and found that the preferable promoter was located in 1200 bp upstream of pri-miR-206. In this region, many key transcription factors, including MyoD, c-Myb, CEBPα/β, AP-4, RAP1, Brn2, GATA-...
The antitumor and anti-invasive activities of the low-molecular-weight macrocyclic ketones (MCKs), such as musk secreted from the mammalian genital glands and musk released from relatively unkown plants, were investigated comparatively together with the enhancement of the effects in combination with hyperthermia. Ehrlich ascites tumor cells were treated with each MCK and cultured, followed by e...
HPV infrequently persists and progresses to cervical cancer. We examined host genetic factors hypothesized to play a role in determining which subset of individuals infected with oncogenic human papillomavirus (HPV) have persistent infection and further develop cervical pre-cancer/cancer compared to the majority of infected individuals who will clear infection.We evaluated 7140 tag single nucle...
Open dumping activities at the Batu Layang TPA can potentially cause leachate pollution to environment. Leachate that seeps into ground contaminate groundwater. Most people around use groundwater for MCK (bath, wash, toilet) purposes. If is contaminated with and used sustainably by community, it will impact health problems. Therefore, necessary manage distribution of leachate. One management sy...
Developers are using real-time analysis tools in the development stage, to debug real-time events either not observable during “run-stop” debug sessions, or limited by the requirements of the application; such as inherently not freezable systems like engine control or pace makers. Furthermore, engineers are using real-time analysis tools in their final development stage to do performance tuning...
We are using summarising as a way of studying large-scale discours¢~ structure. Much computationally-orieuted work on disconrse structure ha.s been concerned with dialogue, rather than with 'single-source' text.. Some prop()sals haw. been made for singh~-soul'ce text e.g. l~hetorical Structure Theory (Mann ;rod Tholnpsoll 1987), I)nt al'~' open to criticism (e.g. Moore and I)olla(:k 1.q92); and...
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