Both mannitol and sucrose (Suc) are primary photosynthetic products in celery (Apium graveolens L.). In other biological systems mannitol has been shown to serve as a compatible solute or osmoprotectant involved in stress tolerance. Although mannitol, like Suc, is translocated and serves as a reserve carbohydrate in celery, its role in stress tolerance has yet to be resolved. Mature celery plan...

The effects of dietary fructooligosaccharide (FOS) and dietary mannitol on the absorption of Ca and Mg in a short term feeding trial were studied. Adult Wistar rats were divided into three groups and fed diets containing 0, 8% FOS or 8% mannitol for seven days. Daily intake and feces were monitored for three days to determine the apparent absorption of Ca and Mg. At the last day of the feeding ...

This international phase III study of inhaled dry powder mannitol was a randomised, double-blind, 26-week study, followed by a further 26-week, open-label (OL) extension. 324 cystic fibrosis (CF) patients were randomised, in a 3:2 ratio, to mannitol (400 mg b.i.d.) and control groups. The primary efficacy end-point was to determine the change in forced expiratory volume in 1 s (FEV₁) over the d...

It has been postulated that hypertonic saline (HS) might impair the antimicrobial effects of defensins within the airways. Alternative non-ionic osmotic agents such as mannitol may thus be preferable to HS in promoting bronchial mucus clearance (BMC) in patients with cystic fibrosis (CF). This study reports the effect of inhalation of another osmotic agent, dry powder Mannitol (300 mg), compare...

BACKGROUND Eosinophilic airway inflammation has successfully been used to tailor anti-inflammatory therapy in chronic obstructive pulmonary disease (COPD). Airway hyperresponsiveness (AHR) by indirect challenges is associated with airway inflammation. We hypothesized that AHR to inhaled mannitol captures eosinophilia in induced sputum in COPD. METHODS Twenty-eight patients (age 58 ± 7.8 yr, p...

Beta2-agonists and osmotic agents stimulate mucociliary clearance (MCC) via different mechanisms which could potentially interact. The effects of inhaling terbutaline in combination with mannitol on MCC were investigated in nine healthy (aged 19+/-1 yrs) and 11 mild (aged 21+/-4 yrs) asthmatic subjects. Using 99mTc-sulphur colloid radioaerosol and a gamma camera, MCC was studied on four separat...

d-mannitol is a common six-carbon sugar alcohol, which widely used in food, chemical, pharmaceutical, and other industries. Polymorphism defined as the ability of materials to crystallize into different crystal structures. It has been reported for long time that three polymorphs: β, δ, α. These polymorphs have unique physicochemical properties, thus affecting industrial applications d-mannitol....