Background: Despite the fact that liver steatosis is a very frequent condition mainly due to alcohol comsumption and metabolic syndrome, yet there is no consensus regarding appropriate therapy. Aim and study design: Open label nonrandom study in order to assess efficiency of liver protective phytoproducts in patients with nonalcoholic steatohepatitis(NASH) Patients and methods: 30 patients , 11...

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder. It is uncertain if simple steatosis, the initial and prevailing form of NAFLD, sensitizes the liver to cholestasis. Here, we compared the effects of obstructive cholestasis in rats with a normal liver versus rats with simple steatosis induced by a methionine/choline-deficient diet. We found that plasma liver enz...

OBJECTIVE To characterize the association of low HbA(1c) values (<4.0%) with liver enzymes and steatosis. RESEARCH DESIGN AND METHODS Cross-sectional study of 12,533 participants without diabetes aged <20 years in the Third National Health and Nutrition Examination Survey (1988-1994). Logistic regression models were adjusted for demographic, lifestyle, and health status variables. RESULTS H...

INTRODUCTION Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the developed world (1). NAFLD refers to a spectrum of liver disorders occurring due to abnormal fat deposition in the liver, which ranges in severity from simple hepatic steatosis with no inflammation, to steatohepatitis (NASH) which can progress to liver cirrhosis. The diagnosis of NAFL...

Hepatic steatosis and liver degeneration are prominent features of the zebrafish ducttrip (dtp) mutant phenotype. Positional cloning identified a causative mutation in the gene encoding S-adenosylhomocysteine hydrolase (Ahcy). Reduced Ahcy activity in dtp mutants led to elevated levels of S-adenosylhomocysteine (SAH) and, to a lesser degree, of its metabolic precursor S-adenosylmethionine (SAM)...

Defective liver gluconeogenesis is the main mechanism leading to fasting hyperglycemia in type 2 diabetes, and, in concert with steatosis, it is the hallmark of hepatic insulin resistance. Experimental obesity results, at least in part, from hypothalamic inflammation, which leads to leptin resistance and defective regulation of energy homeostasis. Pharmacological or genetic disruption of hypoth...

Nonalcoholic fatty liver disease is the most frequent liver disease. Ezetimibe, an inhibitor of intestinal cholesterol absorption, has been reported to ameliorate hepatic steatosis in human and animal models. To explore how ezetimibe reduces hepatic steatosis, we investigated the effects of ezetimibe on the expression of lipogenic enzymes and intestinal lipid metabolism in mice fed a high-fat o...

BACKGROUND clinical data on impact of the Mediterranean diet on the the stage of non alcoholic fatty liver disease are limited and these studies have heterogeneous designs. AIM we decide to explore any potential associations between adherence to the Mediterranean diet and histological characteristics of patients with NAFLD. METHODS a sample of 82 patients was analyzed in a cross sectional s...

Hepatic steatosis is a growing public health concern. Nonalcoholic fatty liver is increasingly common in Western societies and may lead to steatohepatitis, fibrosis, and cirrhosis, possibly triggered by lipid peroxidation. The relation of fatty liver to obesity, type II diabetes, and/or metabolic syndrome is significant. One aspect these related disorders share is increased serum-free fatty aci...