In this study, solvent-cast polymeric films containing ionic liquid lidocaine/aspirin for transdermal patches were developed. Solvent-cast prepared from two polymers, pectin and Eudragit® NE 30D, by drying the solution in a hot air oven at 70 ± 3 °C 10 h. Glycerin was used as plasticizer. Lidocaine aspirin form loaded into patches. The physicomechanical properties of characterized texture analy...

yog-ice cream (frozen yogurt), is a kind of frozen dessert which has similar features to ice cream in physical and appearance characteristics. recently, there has been a growing interest in using frozen yogurt due to existence of lactic acid bacteria & fermentation processing. besides, yog-ice cream contains lower levels of sugar, fat & emulsifiers than ice cream. this research was conducted to...

The survival of cultured L1210 cells exposed to bleomycin A2 (BLM A2) was markedly decreased by coincubation with the local anesthetic lidocaine. The potentiation occurred with concentrations of lidocaine that were nontoxic and was dependent upon both the concentration of lidocaine and BLM A2. A 1000-fold decrease in survival was seen with a 1-h exposure to 8 mM lidocaine and 10 microM BLM A2 c...

PURPOSE It has been reported that the addition of epinephrine and/or bicarbonate to local anesthetic enhances the depth of epidural blockade and that initial partial bolus injection results in greater caudal spread. We evaluated the anesthetic effects of lidocaine with epinephrine and/or bicarbonate injected into the epidural space by bolus or catheter injection. METHODS Forty-four patients u...

Lidocaine is a frequently administered anti-arrhythmic drug, particularly useful in emergency situations because of its rapid onset of action (1). Therapeutic drug monitoring of lidocaine is recommended because of its potent central nervous system toxicity. Moreover, lidocaine has been implicated in numerous accidental and homicidal deaths (2). Thus its chemical stability in patients’ specimens...

introduction: nowadays, spinal anesthesia is associated with few complications in many surgical practices especially the elective caesarean which is taken as a suitable replacement for general anesthesia. different drugs are used for spinal anesthesia. this study aims to compare lidocaine 5% in combination with meperidine 5% plus lidocaine 5% for spinal anesthesia in non-emergency cesarean pati...

conclusions lidocaine-meperidine-diltiazem gel provides significantly better pain control than lidocaine-diltiazem gel and lidocaine gel alone during transrectal ultrasound guided prostate biopsy and probe insertion. this mixture gel is safe, easy to administer and well accepted by patients. results the mean of visual analog pain scale was 4.5 in group a, 3.5 in group b, and 2.0 in group c duri...

background: nicotine can activate dopaminergic neurons within the ventral tegmental area (vta). however, there is no evidence about complete inhibition of vta on nicotine reinforcement. methods: in the present study, we used conditioned-place preference (cpp) method to study the effect of transient inhibition of left and/or right side of the vta by lidocaine on nicotine reward properties. male ...

We examine the progress that has been made towards the development of topical treatments for premature ejaculation (PE). Although generally regarded as one of the most common male sexual problems, the lack of approved pharmacological agents for PE means that treatment options are limited to behavioural therapy, where available, and the use of drugs 'off-label'. There are various theories on the...

Following stroke, many patients suffer from chronic motor impairment and reduced somatosensation in the stroke-affected body parts. Recent experimental studies suggest that temporary functional deafferentation (TFD) of parts of the stroke-affected upper limb or of the less-affected contralateral limb might improve the sensorimotor capacity of the stroke-affected hand. The present study sought e...