The concept of CNS preventive therapy in childhood all is based on the assumption that undetectable CNS leukemia is present in most patients at the time of diagnosis, residing in that "sdnctuary site" protected by the blood-brain barrier from cytotoxic concentrations of most systemically ad­ministered antileukemic agents. Studies in the 1960s demonstrated that administration of 2400 rad cranial...

acute myeloblastic leukemia is the most frequent cancer in adults and the patients have a wide range of sub-classes. hla dr negative cases represent one of the major immune-phenotypic classes.  hla-dr is routinely used to distinguish acute promyelocytic leukemia (apl) from other aml subclasses based on the immunophenotype. the tgf-b signaling pathway, as a critical regulator, guides different v...

Myelodysplastic syndromes (MDS) comprise a heterogeneous group of malignant hematopoietic stem cell disorders that are characterized by ineffective blood production and variable risk transformation into acute myeloid leukemia. In recent years, significant progress in MDS biological research has allowed the addition new drugs to few existing therapeutic options. This article presents recommendat...

background: methotrexate has an important role in treatment of acute leukemia. we measured methotrexate level in csf and blood of children with acute lymphoblastic leukemia to determine complications and outcomes. materials and methods: one hundred and twenty patients (73 male, 47 female), with mean age at diagnosis of 6.1 years (11mo_15years) entered the study. patients were divided into two g...

abstract background: invasive fungal infection is an opportunistic infection caused commonly by mucoraccae and aspergillus. it mostly occurs in patients with underlying disease. since it has a high mortality and morbidity rate, considering a treatment strategy seems necessary.   objective: since there has not been a clear protocol for treating these patients, we decided to establish a protocol ...

Ecthyma Gangrenosum is a severe skin disease commonly associated with Pseudomonas aeruginosa septicemia, there an increased risk of infection in patients malignancy undergoing chemotherapy notably Chronic lymphocytic leukemia (CLL). We present case report CLL patient infested by P. aeruginosa.

An accurate early-stage leukemia diagnosis plays a critical role in treating and saving patients’ lives. The two primary forms of are acute chronic leukemia, which is subdivided into myeloid lymphoid leukemia. Deep learning models have been increasingly used computer-aided medical (CAD) systems developed to detect This article assesses the impact widely applied techniques, mainly data augmentat...

Abstract CD4 T cell exhaustion is associated with relapse in B leukemia (B-ALL) patients. However, checkpoint blockade not effective treating B-ALL. Using a murine model of B-ALL, we demonstrate that induced cells had unique regulatory-cytotoxic phenotype (T rctx) preferential expression markers (PD1/TIM3) as well IL10 and c-Maf, which are immunosuppressive Tr1 cells. Leukemia acting APCs elici...

Background: Bone marrow transplantation (BMT) is considered as a curative therapy for a broad range of diseases. However, complications such as relapse and graft versus host disease (GVHD) may be observed following BMT. Chimerism analysis serves as a reliable indicator of transplant outcome. Complete chimerism refers to the complete replacement of hematopoietic system by donor cells, while mixe...

a 54 year old man with history of cardiomyopathy and chronic fibrillation first presented with bloody diarrhea. then during the assessment of his abnormal lab. data revealed cast nephropathy in renal biopsy, gamma peak in protein electrophoresis and fine lytic lesions in skull graphy. his bone marrow aspiration showed multiple myeloma and blood smear revealed plasma cell leukemia. our patient w...