Original WBN/Kob male rats commonly develop chronic pancreatitis by the age of 3 months, while diabetes mellitus occurs at 9 months. In contrast, female rats of this strain do not show pancreatitis or diabetes. The WBN/Kob-fatty rat is a homozygous (fa/fa) congenic strain for the fa allele of the leptin receptor gene (Lepr). In WBN/Kob-fatty rats, both females and males provide a model of non-i...

[1] We describe the Library of Experimental Phase Relations (LEPR), which is a new Web-based database of experiments pertaining to magmatic phase equilibria. The database includes information from experiments related to natural or near-natural magmatic silicate phase equilibria. At present, the database includes more than 6,600 experiments with liquids ranging in composition from komatiite to r...

OBJECTIVE To investigate the association between leptin levels, polymorphisms in the leptin receptor (LEPR) gene, and weight gain. RESEARCH METHODS AND PROCEDURES From two large prospective cohorts in The Netherlands (n = 17,500), we compared the baseline leptin of 259 subjects who had gained an average of 12.6 kg (range 5.5 to 33 kg) with 277 subjects who kept stable weight (range -2.6 to 3....

Leptin plays a pivotal role in regulation of energy balance. Via unknown central pathways, leptin also affects peripheral glucose homeostasis and locomotor activity. We hypothesized that, specifically, pro-opiomelanocortin (POMC) neurons mediate those actions. To examine this possibility, we applied Cre-Lox technology to express leptin receptors (ObRb) exclusively in POMC neurons of the morbidl...

Context Genetic defects affecting the expression and function of factors involved in pituitary development have been found to be associated with congenital hypopituitarism (CH). However, for most cases of CH, the etiology remains unknown. Case Description We present an unusual case of an infant with CH, associated with septo-optic dysplasia with an absent anterior pituitary and an ectopic pos...

The aim of this study was to identify SNPs in leptin (LEP), leptin receptor (LEPR) and growth hormone (GH) genes in order to analyze genetic diversity of Slovak Spotted cattle. The total numbers of blood samples were taken from 353 Slovak Spotted cows originating from four farms. Genomic DNA was isolated by phenol-chloroform extraction method and analyzed by PCR-RFLP method. After digestion wit...

Bone marrow stem cells participate in tissue repair processes and may have roles in skin wound repair. Diabetes is characterized by delayed and poor wound healing, and type 1 diabetes seems to lead to stem cell dysfunction. Hence, stem cell dysfunction could contribute to poor healing, and stem cell–based therapies may be efficacious in diabetic wounds. We investigated the potential of exogenou...

Title: The CNS glucagon-like peptide-2 receptor in the control of energy balance and 1 glucose homeostasis 2 3 Xinfu Guan 4 USDA/ARS Children's Nutrition Research Center, Department of Pediatrics; Division 5 of Diabetes, Endocrinology & Metabolism, Department of Medicine, Baylor College of 6 Medicine, Houston, TX, USA 7 8 Running head: the CNS GLP-2 promotes glycemic control 9 Address for repri...