The multilayered mammalian neocortex develops by the coordinated immigration and differentiation of cells that are produced at distant sites. Correct layering requires an extracellular protein, Reelin (Reln), an intracellular signaling molecule, Disabled-1 (Dab1), and an E3 ubiquitin ligase, Cullin-5 (Cul5). Reln activates Dab1, which is then degraded by Cul5. Here we test whether Cul5 regulate...

PURPOSE To determine whether the fracture strengths and failure types differed between metal and zirconia frameworks veneered with pressable or layering ceramics. MATERIALS AND METHODS A phantom molar tooth was prepared and duplicated in 40 cobalt-chromium abutments. Twenty metal (IPS d.SIGN 15, Ivoclar, Vivadent, Schaan, Liechtenstein) and 20 zirconia (IPS e.max ZirCAD, Ivoclar) frameworks w...

Models of complex systems are widely used in the physical and social sciences, and the concept of layering, typically building upon graph-theoretic structure, is a common feature. We describe an intuitionistic substructural logic that gives an account of layering. The logic is a bunched system, combining the usual intuitionistic connectives, together with a non-commutative, non-associative conj...

Using the NASA Goddard Institute for Space Studies (GISS) climate model, it is shown that with proper choice of the gravity wave momentum flux entering the stratosphere and relatively fine vertical layering of at least 500 m in the upper troposphere-lower stratosphere (UTLS), a realistic stratospheric quasi-biennial oscillation (QBO) is modeled with the proper period, amplitude, and structure d...

We present heat-capacity data detailing the evolution of the first six layers of argon adsorbed on graphite foam. The second and third layers have liquid-solid-gas triple points similar to the first layer. These layers exhibit a phase diagram consisting of two-dimensional solid, liquid, and gas phases on top of a solid film. Above the temperatures of the individual-layer triple points, the melt...

[1] Pressure-release melting at mid-ocean ridges generate compositional and rheological layering in the oceanic mantle that may control the evolution of the oceanic lithosphere. We use dynamic models coupled with melting and petrological models to explore 1) the influence of this layering on the development of small-scale convection under the oceans, 2) its role in determining the thickness of ...

Using a generalized Landau theory involving orientational, layering, tilt, and biaxial order parameters we analyze the smectic-A* and smectic-C* (Sm-A*-Sm-C*) transitions, showing that a combination of small orientational order and large layering order leads to Sm-A*-Sm-C* transitions that are either continuous and close to tricriticality or first order. The model predicts that in such systems ...