نتایج جستجو برای: ku70

تعداد نتایج: 763  

Journal: :Cancer research 2010
Kaisa R Luoto Alice X Meng Amanda R Wasylishen Helen Zhao Carla L Coackley Linda Z Penn Robert G Bristow

MYC regulates a myriad of genes controlling cell proliferation, metabolism, differentiation, and apoptosis. MYC also controls the expression of DNA double-strand break (DSB) repair genes and therefore may be a potential target for anticancer therapy to sensitize cancer cells to DNA damage or prevent genetic instability. In this report, we studied whether MYC binds to DSB repair gene promoters a...

2017
Joyita Hazra Pooja Mukherjee Asif Ali Soumita Poddar Mahadeb Pal

An involvement of components of DNA-break repair (DBR) complex including DNA-dependent protein kinase (DNA-PK) and poly-ADP-ribose polymerase 1 (PARP-1) in transcription regulation in response to distinct cellular signalling has been revealed by different laboratories. Here, we explored the involvement of DNA-PK and PARP-1 in the heat shock induced transcription of Hsp70A1A. We find that inhibi...

Journal: :Indian journal of experimental biology 2011
Miguel J Ruiz-Gómez

Telomeres solve the end-replication problem. Previous results suggested a relation between Yku70/80 and proteins Tell and Rad50 in telomere stabilization. Inactivation of any of these genes lead to a shortening of telomeres, while in ku70 tell or ku70 rad50 double mutants a drastic amplification of Y' elements was found. The biological significance of this observation is not clear. To further c...

2016
Chih-Chao Liang Martin A. Cohn

The human genome is guarded against mutations by several DNA repair pathways. Common for all pathways, is the initiating event of detecting the DNA damage. This initial event is followed by the coordinated recruitment of various other DNA repair proteins needed for the repair. For instance, the MSH2/MSH6 complex detects DNA mismatches, while the MRN or KU70/KU80 complexes detect double strand b...

Journal: :Biochemical and Biophysical Research Communications 2017

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