Chandra, R. K. (1973). Archives of Disease in Childhood, 48, 864. Reduced bactericidal capacity of polymorphs in iron deficiency. Intracellular bacterial killing by polymorphonuclear leucocytes and reduction of nitro-blue tetrazolium were defective in 12 children with iron deficiency anaemia. Opsonic activity of plasma and phagocytosis were normal. The abnormalities were corrected quickly by pa...

Within the last 18 months there have developed two theories concerning the inorganic factors which influence hematopoietic processes. (I) In rats on a basal diet of milk and iron, supplementary copper alone will stimulate a maximum hemoglobin production. (2) On such a diet a group of elements including copper produces a maximum hemoglobin response while copper alone is slightly less effective. ...

The importance of copper as a supplement to iron for hemoglobin regeneration in anemic rats was first demonstrated 4 years ago by Hart, Steenbock, Waddell, and Elvehjem (1). This work showed definitely that in the presence of copper, soluble inorganic iron salts can be used directly for hemoglobin formation. Since that time a number of workers have studied factors affecting hemoglobin productio...

The efficacy of iron therapy in nutritional anaemia, which has been shown to be of such common occurrence in infants and adults (Mackay"6; Faber6; Davidson et al'; Fullerton') is apparently dependent on the administration of large doses of iron if given orally (Heath"; Witts"). In this connection it is interesting to recall that the use of large doses was first advocated in 1832 by Blaud'. Only...

The behavior in vivo of transferrin in loading and unloading iron from its two sites was examined in rats. Radioiron entering the plasma from the gastrointestinal tract in iron-deficient, normal and iron-loaded rats did not differ in its subsequent tissue distribution between erythroid marrow and liver of normal recipients from a second isotope added to the same plasma in vitro. Loading studies...

Bacterial biofilms are thought to aid in the survivability of a variety of intractable infections in humans. Specifically, biofilm production in Pseudomonas aeruginosa has been shown to play a significant role in chronic infection of cystic fibrosis (CF) patients. Unfortunately, no clinically effective inhibitors of biofilm formation are available. A rapid screen of 4509 compounds for nonantibi...

Dicamba (3,6-dichloro-2-methoxybenzoicacid) is a highly mobile pre- and post-emergence herbicide that has been detected in ground water. We determined the potential of zerovalent iron (Fe0) to remediate water contaminated with dicamba and its common biological degradation product, 3,6-dichlorosalicylic acid (DCSA). Mixing an aqueous solution of 100 microM dicamba with 1.5% Fe0 (w/v) resulted in...

DOI: 10.5581/1516-8484.20110064 Hematology and Oncology Department, Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, SP, Brazil Rodolfo Delfini Cançado From a practical standpoint, it is recommendable to adopt some measures in order to succeed in minimizing the adverse events and improve adherence to oral iron supplementation treatment, such as splitting the recommended dail...

An improved protocol for the formal elimination of propene from organic substrates is reported. This process entails the ozonolytic conversion of an alkene to a methoxy hydroperoxide which undergoes fragmentation mediated by copper and iron. The use of soluble Cu(BF4)2 and Fe(BF4)2 results in reproducible results up to a 100 gram scale.