Peyronie disease can be physically and psychologically devastating for subjects and their partners. Collagenase Clostridium histolyticum (CCh), a purified mixture of AUX-I and II collagenases, is an intralesional, minimally invasive intervention with evidence of tolerability and efficacy in subjects with PD and is approved by the United States Food and Drug Administration for use in adults who ...

The aim of the study was to evaluate the efficacy of intralesional triamcinolone acetonide injection in primary and recurrent chalazion. The study included 30 patients with primary and recurrent chalazion (37 cases) and 24 patients as a control group. Patients with primary and recurrent chalazion received intralesional injection of 0.1 to 0.2 mL triamcinolone acetonide (40 mg/mL). Control group...

BACKGROUND Various treatment strategies for low-grade chondrosarcomas with variable outcomes have been reported in the literature. The aim of this study was to assess the oncological and functional outcomes associated with intralesional curettage followed by adjuvant therapy comprising high-speed burring, thermal cauterization, and bone cementation with polymethylmethacrylate. METHODS We perf...

INTRODUCTION We present a case of lipoatrophy treated successfully with intralesional normal saline injections. Localized lipodystrophy, or lipoatrophy, presents as focal loss of subcutaneous fat with variable overlying skin changes and depth depending on the cause. Lipoatrophy could result from both oral and local intralesional corticosteroid use, with the buttocks and proximal extremities bei...

Background: Alopecia areata is a common disorder of hair occurring on any hair bearing site of the body and having a great psychosocial impact. Aims: To assess the demographic pattern, clinical aspects, associations and therapeutic response of AA in a tertiary care teaching hospital. Materials & methods: All patients diagnosed with alopecia areata were included in the study. With due consent, t...

Local anesthetics are commonly utilized in the practice of dermatology. Minimizing local anesthetic injection pain can be beneficial to both physicians and patients. Easily implemented techniques that reduce injection pain of intralesional local anesthetics are reviewed.

R egional chemotherapy usually involves using intra-arterial or intracavitary drug infusion to increase drug concentration within tumor-containing tissue while minimizing systemic toxicity. It has long been used as a treatment modality for various malignancies including melanoma, soft tissue sarcoma, and primary brain tumors. Analogous to regional chemotherapy, intralesional chemotherapy has be...

INTRODUCTION Sudden swelling of the neck is an emergency situation that can be life-threatening for the patient. Therefore, an understanding of the possible underlying pathology is of great importance. Sudden massive swelling of the neck because of intralesional bleeding of a thyroid adenoma is seldom encountered but must be considered. Such massive swelling caused by spontaneous bleeding of a ...

Objective To investigate the spatiotemporal evolution of venous narrowing in newly developing MS lesions in a longitudinal MRI study including susceptibility-weighted images (SWIs). Methods We retrospectively investigated serial MR examinations of 18 patients with MS acquired on a 3T MRI system including SWI for acute contrast-enhancing lesions with at least 1 MRI examination before contrast ...