Abstract The O-GlcNAc transferase (OGT) is an essential enzyme that mediates protein O-GlcNAcylation, a unique form of posttranslational modification many nuclear and cytosolic proteins. Recent studies observed increased OGT O-GlcNAcylation level in broad range human cancer tissues compared to adjacent normal tissues, indicating universal effect promoting tumorigenesis. Here, we show for tumor ...

Noroviruses are responsible for a large majority of non-bacterial gastroenteritis outbreaks worldwide. They are considered to be the leading cause of foodborne disease outbreaks and are classified as category B biodefense agents. Noroviruses pose huge medical and economic burdens to the global community: While they display a rapid course of infection in healthy adults, several risk groups inclu...