A gradient reversed-phase high performance liquid chromatography (HPLC) method was developed for the assay of cetrorelix acetate, a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity used in infertility treatment. The HPLC method, which is used to determine cetrorelix in bulk and pharmaceutical dosage forms, was validated per ICH guidelines. The chromatograph...

Easily degradating and various isomeric forms of rapamycin (Sirolimus) face the determination of this compound to many challenges. In this study, we developed and validated the isocratic reversed phase high performance liquid chromatographic (RP-HPLC) method for rapamycin. Separation was performed on a C8 column (MZ, 15 × 4.6 mm, 5 µm particle size) using methanol:water (80:20 v/v) as the mobil...

Neutralinos annihilating in the center of the Sun or the Earth may give rise to a detectable signal of neutrinos. We derive the indirect detection rates for neutrino telescopes in the minimal supersymmetric extension of the standard model. We show that even after imposing all phenomenological and experimental constraints that make the theories viable, regions of parameter space exist which can ...

High energy particles are produced by the annihilation of dark matter particles in our galaxy. These are presently searched for using balloon-borne an-tiproton and positron detectors and large area, deep underground neutrino telescopes. Dark matter particles, trapped inside the sun, are an abundant source of such neutrinos. From both the cosmological and particle physics points of view the ligh...

Unstable relics with lifetime longer than the age of the Universe could be the dark matter today. Electrons, photons and neutrinos are a natural outcome of their decay and could be searched for in cosmic rays and in γ-ray and neutrino detectors. I compare the sensitivities of these three types of searches to the mass and lifetime of a generic unstable particle. I show that if the relics constit...

The behavior of quantum mechanical state functions under selective rotations is discussed. If a t~o-level transition is phase shifted vrith composite z pulses, the component state function shared ~ith a connected transition can be multiplied by i, thereby shifting the corresponding coherence into an orthogonal channel. Application to the sensitive indirect detection of NMR transitions is demons...

A novel indirect electrochemical protocol for the electroanalytical detection of phenols is presented for the first time. This methodology is demonstrated with the indirect determination of the target analytes phenol, 2-chlorophenol, 4-chlorophenol and 2,4-dichlorophenol through an electrochemically adapted optical protocol. This electrochemical adaptation allows the determination of the above ...

A new method of offline solid-phase microextraction coupled with capillary electrophoresis (CE) [in an uncoated capillary using borax and boric acid in acetonitrile-water (40:60) as the running buffer] with UV detection at 254 nm is presented and used for direct determination of trace biomedically important retinoic acid (RA) without any derivation. As low as 138 ng/mL RA in aqueous solution ca...

The determination of biogenic amines in alcoholic beverages is important to assess the potential risks associated with the consumption of high concentrations of these compounds. In addition, product storage conditions and the length of storage can cause the formation of biogenic amines that reduce product quality. We report a new method using cation-exchange chromatography with either suppresse...