With increase in the number of polio cases, Nigeria serves as the primary threat to a polio free world. The “good” the bad” and “the ugly” aspects of polio vaccination in Nigeria is discussed. In the ‘good’ aspect the number of wild poliovirus cases declined by over 90%, cVDPV 2 cases declined by 82%. Similarly, genetic clusters of both wild poliovirus type 1 and type 3 have reduced form 18 and...

AIM To estimate the incremental net benefits (INBs) of a hypothetical ideal vaccine with all of the advantages and no disadvantages of existing oral and inactivated poliovirus vaccines compared with current vaccines available for future outbreak response. METHODS INB estimates based on expected costs and polio cases from an existing global model of long-term poliovirus risk management. RESU...

The role of routine vaccination against poliomyelitis for the post-certification era remains an important area for policy decision-making. Two critical decisions need to be taken: first, to continue or discontinue vaccination with the live attenuated oral poliovirus vaccine (OPV); and second, if OPV is to be discontinued, whether vaccination with inactivated poliovirus vaccine (IPV) is needed. ...

The lack of treatment for poliomyelitis doing that only means of preventing is immunization with live oral polio vaccine (OPV) or/and inactivated polio vaccine (IPV). Poliomyelitis is a very contagious viral infection caused by poliovirus. Children are principally attacked. In this paper, we assess the impact of vaccination in the control of spread of poliomyelitis via a deterministic SVEIR (Su...

OBJECTIVE IgG and IgA immunocompetence of children with wild poliovirus poliomyelitis and non-polio acute flaccid paralysis. METHODS 932 cases of acute flaccid paralysis, reported in 2008-2009, were tested for presence of polio and non-polio enteroviruses according to the WHO standards. Serum IgA and IgG levels were determined by sandwich ELISA. RESULTS Mean (SD) IgA levels [0.87 (0.62)g/L;...

Poliomyelitis is one of few diseases that can be eradicated. The virus cannot survive outside the body and effective vaccine is available to protect children and stop transmission. Today, there are 3 million children each year saved by the oral polio vaccine (OPV) and globally the reported cases have declined from 50,000 to 7,000 in 1999. At present, 20 countries may remain at risk of continued...

Despite high polio vaccine coverage, Israel recently experienced a silent surge in the transmission of wild poliovirus in the population. In this issue of Clinical Infectious Diseases, Shulman and colleagues report interesting data about the antigenic and pathogenic features of the poliovirus strain circulating in that country. Poliovirus, the causative agent of poliomyelitis, replicates mainly...