context celiac disease (cd) is defined as a permanent intolerance to ingested gluten. the intolerance to gluten results in immune-mediated damage of small intestine mucosa manifested by villous atrophy and crypt hyperplasia. these abnormalities resolve with initiationa gluten-free diet. evidence acquisition pubmed, ovid, and google were searched for full text articles published between 1963 and...

Sebaceous adenitis is an autoimmune disease that is seen mainly in the Standard Poodle, Akita, and English Springer Spaniel. The incidence of the disease in Standard Poodles appears to be low at this time but increasing in frequency over time. The disease is a generalized skin disorder associated with an attack by the dog’s own immune system against the sebaceous glands. The breed is known to s...

Musculoskeletal (MSK) disease is the most common extra-intestinal manifestation of inflammatory bowel (IBD); however, full spectrum MSK manifestations remains poorly characterized. The published literature predominately focused on peripheral and axial spondyloarthritis (SpA). However, prevalence more common, non-inflammatory conditions, such as osteoarthritis (OA) fibromyalgia (FM), has not bee...

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS). This highlydisabling disorder is characterized by a variable clinical course. MS is a heterogeneous disease with acomplex pathology and significant social and economic impact. MS is associated with dysfunction ofparts of the nervous system which results in a range of signs and symptoms, ...

Immunoglobulin G4-related disease (IgG4 RD) is a systemic immune-mediated inflammatory that presents as multiple organ dysfunction or mass lesions with lympho-plasmacytic infiltration. However, there are few case reports presenting central nervous system involvements. Herein, we report of 70-year-old man recurrent ischemic stroke which induced by IgG4 RD. RD should be considered and treated one...

Systemic sclerosis is a prototypic fibrotic disease characterised by accumulation of excessive extracellular matrix in affected tissues, including skin, lung, and walls blood vessels, that can lead to pulmonary hypertension, scleroderma renal crisis, or digital ischaemia. The constellation clinical manifestations makes systemic one the most challenging immune-mediated rheumatic diseases treat. ...

Bone serves as a multifunctional organ in avian species, giving structural integrity to the body, aiding locomotion and flight, regulating mineral homeostasis, supplementing calcium for eggshell formation. Furthermore, immune cells originate reside bone marrow, sharing milieu with cells, indicating potential interaction functions. In prevalence of gastrointestinal diseases can alter growth resp...

The prevailing notion is that lupus nephritis is mediated by autoantibodies, particularly those that bind to DNA and/or glomeruli. However it has become apparent that the development of immune-mediated renal disease is contingent upon additional factors including innate stimuli and host genetics. The purpose of this review is to evaluate our current understanding of three factors that can poten...

Introduction Chronic granulomatous disease (CGD) is a primary immune deficiency that characterized with recurrent infections and granuloma formation. A variety of autoimmune disorders and immune-mediated phenomena such as inflammatory bowel disease, discoid lupus erythematous, juvenile idiopathic arthritis, Ig A nephropathy, sarcoidosis, rheumatoid arthritis, idiopathic thrombocytopenia, eosino...