During lipopolysaccharide (LPS)-induced endotoxemia, increased intrasplenic fluid efflux contributes to a reduction in plasma volume. We hypothesized that splenic sympathetic nerve activity (SSNA), which increases during endotoxemia, limits intrasplenic fluid efflux. We reasoned that splenic denervation would exaggerate LPS-induced intrasplenic fluid efflux and worsen the hypotension, hemoconce...

Stanniocalcin-1 (STC-1) is made by kidney collecting duct cells for autocrine and paracrine targeting of nephron cell mitochondria. Here, the ligand stimulates respiratory uncoupling and calcium uniport activity. However, the underlying purpose of these actions and how the renal gene is regulated are poorly understood. In a previous study, we described the time-dependent, stimulatory effects of...

Heart rate variability (HRV) decreases during hemorrhage, and has been proposed as a new vital sign to assess cardiovascular stability in trauma patients. The purpose of this study was to determine if any of the HRV metrics could accurately distinguish between individuals with different tolerance to simulated hemorrhage. Specifically, we hypothesized that (1) HRV would be similar in low toleran...

Background: Serial blood draws for the assessment of a trauma patient’s hemoglobin (sHgb) and hematocrit (sHct) is standard practice. In the event of multiple casualties this process can be time consuming and lead to the inefficient use of valuable resources. A device that would allow for continuous real-time, non-invasive monitoring of hemoglobin and tissue perfusion would not only improve the...

Variants of postural tachycardia syndrome (POTS) are associated with increased ["high-flow" POTS (HFP)], decreased ["low-flow" POTS (LFP)], and normal ["normal-flow" POTS (NFP)] blood flow measured in the lower extremities while subjects were in the supine position. We propose that postural tachycardia is related to thoracic hypovolemia during orthostasis but that the patterns of peripheral blo...

Objective. To determine the leading factor in pathogenesis of intestinal anastomotic failure peritonitis. Methods. The experiment was carried out on non-linear white rats (n=40), divided into 4 equal groups: with peritonitis (group 1), hypovolemia 2), combination 3) and comparison 4). Colonic “end-to-end” anastomosis performed all rats. Peritonitis caused by injection 10% unfiltered feces abdom...

Abstract Objective We evaluated risk factors to determine if there were specific that could predict massive bleeding in nulliparous women with placenta previa. Methods The participants classified into two groups. Women a calculated blood loss ≥ 1,000 mL included the group. without any signs or symptoms related hypovolemia volume < categorized non-massive Results There 28 patients (40.6%) and...