BACKGROUND To determine whether cortisol secretion and glucocorticoid receptors in lymphocytes and monocytes are altered in patients with impaired glucose tolerance, and whether treatment with a hypocaloric diet and metformin could interfere with these aspects. METHODS This is an analytical, interventional, case series study. Patients with impaired glucose tolerance were included. They receiv...

n the December issue of the Journal of Research in Medical Sciences, Alizadeh et al1 have demonstrated that consumption of a legumes-rich hypocaloric diet for 6 weeks reduced some anthropometric measures such as waist, hip, triceps, biceps, subscapular and suprailiac skin fold thicknesses among healthy premenopausal women with central obesity. Beneficiary effects of legumes consumption like red...

Providing rats and mice with access to palatable high fat diets for a short period each day induces the consumption of substantial binge-like meals. Temporal food intake structure (assessed using the TSE PhenoMaster/LabMaster system) and metabolic outcomes (oral glucose tolerance tests [oGTTs], and dark phase glucose and insulin profiles) were examined in Sprague-Dawley rats given access to 60%...

Context In obese men with lowered testosterone levels, testosterone treatment augments diet-associated loss of body fat. Objective We hypothesized that testosterone treatment modulates circulating concentrations of hormonal mediators of fat mass and energy homeostasis in obese men undergoing a weight loss program. Design Prespecified secondary analysis of a randomized, double-blind, placebo...

Results Analysis of four day food records following each testing session revealed average values of 1588 ± 116.7 kcal/day, 43.6 ± 7.3% protein, 35 ± 5.4% carbohydrates, 17.8 ± 7.98% fat throughout the testing period. Additionally, the participant lost 6.09 kg (13.4lb) and 2.5 BMI units. Furthermore both HHBIA (.935; p = .006) and JP7 (.954; p = 0.003) were significantly and positively correlate...

To study the capacity for moderate endurance exercise and change in metabolic fuel utilization during adaptation to a ketogenic diet, six moderately obese, untrained subjects were fed a eucaloric, balanced diet (base line) for 2 wk, followed by 6 wk of a protein-supplemented fast (PSF), which provided 1.2 g of protein/kg ideal body wt, supplemented with minerals and vitamins. The mean weight lo...

OBJECTIVE Non-alcoholic fatty liver disease (NAFLD) is an increasingly recognized health problem. Various treatment strategies such as thiazolidinediones, metformin, lipid-lowering agents and antioxidants have been evaluated. So far, no single intervention has convincingly improved liver histology. Experience of using silymarin alone or in combination with other agents in patients with NAFLD is...

OBJECTIVE To comprehensively compare the effects of a very low-carbohydrate, high-unsaturated/low-saturated fat diet (LC) with those of a high-unrefined carbohydrate, low-fat diet (HC) on glycemic control and cardiovascular disease (CVD) risk factors in type 2 diabetes (T2DM). RESEARCH DESIGN AND METHODS Obese adults (n = 115, BMI 34.4 ± 4.2 kg/m(2), age 58 ± 7 years) with T2DM were randomize...