We experienced two patients with serious arrhythmias associated with the administration of ledipasvir (LDV) and sofosbuvir (SOF). Neither patient took amiodarone, an agent for which concomitant use is prohibited. One patient was 82 years old and hypertensive; the other was 72 years old and had no cardiovascular risk factors such as hypertension or diabetes mellitus. The arrhythmias were both se...

Although pentolinium tartrate is widely used in the treatment of hypertension, there are no reports available regarding some of its cardiovascular effects and its influence on water and electrolyte excretion. The results of the present study indicate that this drug is of value in reducing the mean arterial blood pressure in hypertensive patients. However, the data also indicate the necessity fo...

Objective(s):The aim of this study was to investigate the effects of nutritional saffron (Crocus sativus L.) stigma hydroalcoholic extract on blood pressure (BP) and histology of the aorta in normotensive and hypertensive rats. Materials and Methods:   Saffron (200 mg/kg/day) was given orally for 5 weeks to normotensive and hypertensive rats. Hypertension was induced by NG-nitro-L-arginine meth...

Methods ECV measurement was by EQ-CMR. The T1 mapping sequence was ShMOLLI. The contrast agent was Gadoterate meglumine (Dotarem) at 0.1mmol/Kg (bolus) plus infusion at 15 minutes at 0.0011 mmol/kg/min. CMR was at 1.5T (Siemens Avanto). ECV was measured in 43 well-controlled hypertensive patients from a specialist tertiary centre (median age 56, range 21 to 78, 55% male) and 50 healthy voluntee...

Background: Human neutrophil peptide-1 (HNP-1) is a commonly investigated therapeutic agent. However, its role in hypertensive left ventricular hypertrophy (HLVH) remains unclear. Methods: We measured HNP-1 levels patients with hypertension and treated HLVH rat H9c2 cell models HNP-1. Cardiomyocyte indexes (i.e., single-cell surface area, fibrosis BNP levels, β-MHC levels) were hematoxylin-eosi...

      Lisinopril dihydrate (angiotensin converting enzyme inhibitor) is a lysine derivative of enalaprilat and does not require hydrolysis to exert pharmacological activity. It has an extensive hepatic first pass metabolism resulting in a bioavailabil-ity of 6-60%. To overcome the poor bioavailability of the drug, transdermal patches have been prepared. The present study also aims at optimizati...

Currently, there are no drugs for the specific treatment of hypertensive retinal changes. The main therapy is a systemic disease – disease. Therefore, search ways pharmacological correction changes great interest. aim study: To evaluate possibility injuries with Semax in rat model neuroretinopathy. Materials and methods: was performed by injection N-nitro-L-arginine methyl ester (L-NAME) at dos...

This study aimed to produce a gastroretentive floating tablet of Metoprolol succinate and examine the effects release retardant on in vitro drug release. is β1 selective antagonist used as an Anti-hypertensive, Antiarrhythmic, Anti Angina. has 48% oral bioavailability due limited absorption from lower gastrointestinal tract. The tablets were designed increase stomach retention, prolong release,...

background: early detection of proneness to hypertension may help an individual to lead a healthy life by altering the life style. subjects having the predisposing factors of hypertension tend to show higher and prolonged responsiveness to blood pressure following stress. methods: normotensive, non-smoking healthy sedentary male students and staff of nepal medical college (n=50, age group 18-35...