The effects were studied, in eight healthy volunteers, of premedication with diazepam 0.14 mg kg-1 by mouth or hyoscine 6 micrograms kg-1 + morphine 0.2 mg kg-1 i.m., or no premedication, on toxic symptoms and plasma concentrations after rapid i.v. injection of lignocaine 1 mg kg-1. The alpha 1-acid glycoprotein (AAG) and albumin plasma protein fractions were assessed. A variety of mild central...
