We have read with great interest the article of Simionescu C et al. (“Uterine pseudotumors”, Rom J Morphol Embryol, 2011, 52(3):743–748) [1]. This authors described “signet-ring stromal tumor” (SRST) and consider this lesion as “an unusual reactive process, which is suggested to be more frequent that it has been thought”. The microscopic illustration of the lesion is not reported. This patholog...

Renal inflammatory pseudotumor is a very rare benign condition of unknown etiology characterized by proliferative myofibroblasts, fibroblasts, histiocytes, and plasma cells. In the case we report, the lesion appeared on contrast-enhanced power Doppler US images as a well-defined hypoechoic mass with intratumoral vascularity, and on CT as a low-attenuated mass. Differentiation from malignant ren...

Hemophagocytic lymphohistiocytosis (HLH) is a potentially life-threatening clinical syndrome caused by uncontrolled activation of lymphocytes and histiocytes resulting in high levels of cytokines. Acquired HLH occurs in autoimmune, inflammatory, infectious, and immunosuppressive disorders. Prompt identification and treatment of an underlying triggering cause improves clinical outcome.

Figure 2. Histologic section of the gallbladder showing a granuloma with histiocytes, an eosinophil (small arrow), and a calcified ovum of a Fasciola species measuring 130 mm (large arrow) (hematoxylin-eosin stain; original magnification, 100). Figure 1. Abdominal CT showing a large, irregular, crescent-shaped, calcified density (large arrow) in the proximal duodenum and a calcification (small ...

Patients usually present with a solitary, polypoid, reddish, friable mass. The entire specimen is usually processed in order to rule out a concurrent cholesteatoma. Pathologic examination will reveal a granulation-type tissue with edematous stroma and a high density of capillaries (figure 1) associated with chronic inflammatory cells, including plasma cells, lymphocytes, histiocytes, and eosino...

Histopathological study showed pseudoepitheliomatous hyperplasia of the epidermis and there was a granulomatous inflammatory infiltrate in the dermis composed of histiocytes, eosinophils, and polymorphonuclear cells. Globular structures with a thick, pigmented wall were seen scattered between the inflammatory cells, some of them arranged in the form of a rosary. These structures stained with pe...

Virus-associated hemophagocytic syndrome is a fulminant disorder associated with systemic viral infection and characterized pathologically by multiple-organ infiltration of hemophagocytic histiocytes into the lymphoreticular tissues. This is the first report of a previously healthy adult in whom Human herpesvirus 6 reactivation induced this syndrome with severe hemodynamic and respiratory distr...

The MR imaging appearance of a case of virus-associated hemophagocytic syndrome complicated by diffuse CNS infiltration is presented. Virus-associated hemophagocytic syndrome is a rare condition, precipitated by viral infection and characterized by proliferation of benign histiocytes with phagocytosis. In severe cases, the CNS may be involved.

A histologically benign but locally infiltrating tumor of histiocytes, fibrous histiocytoma, was found in the trachea of a 26-year-old man. Partial resection of the trachea afforded the successful removal of the growth with no evidence of recurrence or metastases 27 months after surgery. Pathology and prognostic aspects of the tumor are discussed.