نتایج جستجو برای: hirudin variant 3

تعداد نتایج: 1893080  

Journal: :The journal of extra-corporeal technology 1999
Nicklett Johnston Michael E Jessen Michael DiMaio Debra S Douglass

The most common anticoagulant used for cardiopulmonary bypass is heparin. An alternate form of anticoagulant therapy is needed for patients who have immune-mediated heparin-associated thrombocytopenia (HIT). Thrombocytopenia causes bleeding and may lead to serious arterial and venous thrombosis. HIT or heparin-induced thrombocytopenia with thrombosis type II (HITT) are both described as adverse...

The computational fluid dynamics (CFD) simulations of gas turbine combustor were performed for CH4<span st...

Hassan Motejadded, Josef Altenbuchner

A new system is presented for the generation of recombinant <span style="font-variant: normal; font-style: normal; font-family: Arial-ItalicMT; color: #231f20; font-size: 10pt...

2014
Kerstin Sandholm Anna J. Henningsson Susanne Säve Sven Bergström Pia Forsberg Nina Jonsson Jan Ernerudh Kristina N. Ekdahl Geetha P. Bansal

AIM Here we investigated the role of complement activation in phagocytosis and the release of cytokines and chemokines in response to two clinical isolates: Borrelia afzelii K78, which is resistant to complement-mediated lysis, and Borrelia garinii LU59, which is complement-sensitive. METHODS Borrelia spirochetes were incubated in hirudin plasma, or hirudin-anticoagulated whole blood. Complem...

Journal: :Blood 2011
Mohammad Al-Tamimi George Grigoriadis Huy Tran Eldho Paul Patricia Servadei Michael C Berndt Elizabeth E Gardiner Robert K Andrews

This study evaluated shedding of the platelet collagen receptor, glycoprotein VI (GPVI) in human plasma. Collagen or other ligands induce metalloproteinase-mediated GPVI ectodomain shedding, generating approximately 55-kDa soluble GPVI (sGPVI) and approximately 10-kDa platelet-associated fragments. In the absence of GPVI ligands, coagulation of platelet-rich plasma from healthy persons induced ...

Journal: :Thrombosis and haemostasis 2006
Erich V De Paula Mariane C F Nascimento Celso D Ramos Margareth C Ozelo Tânia F Machado Ana T Guillaumon Valder R Arruda Joyce M Annichino-Bizzacchi

Emerging findings have demonstrated the critical role of blood clotting factors in the formation and stabilization of embryonic blood vessels. Whether a similar role is true during post-natal angiogenesis remains to be determined. Here we sought to determine whether the suppression of thrombin generation with anticoagulant drugs at doses routinely used for therapeutic purposes would affect the ...

Journal: :Circulation 1991
J H Chesebro V Fuster

In vivo thrombosis after deep arterial injury has been experimentally shown by receptor inhibitors to be mediated predominantly by thrombin activation of platelets and to a lesser extent by thrombin-related fibrin formation. Thrombosis and thrombolysis are dynamic and simultaneous processes that may influence each other, depending on the exposure and concentration of thrombin and administered a...

Journal: :Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie 2010
Ralph M Loreth Gudrun Klose

BACKGROUND: For whole blood aggregation on the Multiplate® system, the use of thrombin inhibitor as anticoagulant is recommended. So far sample tubes containing liquid lepirudin were provided (Dynabyte, Munich, Germany). They are not sterile and have to be stored refrigerated. For better handling now also sterile tubes with dried hirudin, storable at room temperature, are also provided (Dynabyt...

Journal: :The Biochemical journal 1991
A Betz J Hofsteenge S R Stone

Site-directed mutagenesis has been used to examine the importance of each of the acidic C-terminal residues of hirudin in the formation of its complex with alpha-thrombin. The contribution to binding energy of acidic residues in the 11 C-terminal amino acids varied from 2.3 to 5.9 kJ.mol-1. The differences between the contributions of individual residues were smaller than would be expected from...

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