Abstract Background: Investigators were suspicious of tyrosine-methionine-aspartate-aspartate (YMDD) mutations occurred only in patients who were treated by lamivudine. However, YMDD mutations of hepatitis B virus gene (HBV DNA) in patients with chronic hepatitis B (CHB) untreated with antiviral medicines was reported in some studies. The aim of this study was to evaluate YMDD mutations in Ira...

BACKGROUND Viral hepatitis is a serious health burden worldwide. To date, few reports have addressed the prevalence of hepatitis A, B, C, and E in China. Therefore, the general epidemiological parameters of viral hepatitis remain unknown. PRINCIPAL FINDINGS In this cross-sectional study, we performed a serological prevalence analysis of viral hepatitis A, B, C, and E in 8,762 randomly selecte...

conclusions hepatitis b core antibody immunoglobulin m positivity is different in healthy blood donors of different countries according to the prevalence of chronic hepatitis b and its vaccination. based on the current study findings, all positive samples of hepatitis b core antibody in iranian blood banks should be considered as candidates for occult hepatitis b not just the window period infe...

HEPATITIS VIRUS MARKERS IN THE POPULATION OF THE SOUTHERN PLAIN REGION OF HUNGARY; PERINATAL OR TRANSPLACENTAL TRANSMISSION OF HUMAN VIRUSES Nation-wide programmes have been initiated in Hungary for the prevention of perinatal transmission of hepatitis B virus (HBV) in 1995 and mandatory vaccination has been initiated in 2001. The prevalence of hepatitis virus markers have been determined in th...

Hepatitis B virus DNA was extracted from serial serum samples of a hepatitis B surface antigen-negative patient with antibodies to the core protein as the only marker of an infection with hepatitis B virus. This patient showed no symptoms of hepatic injury. Sequencing of the amplified viral DNA demonstrated multiple amino acid changes clustering in surface-exposed regions of the surface protein...

Background: Hepatitis B is a health issue that become major problem worldwide with high morbidity. liver infection caused by Virus. Chronic hepatitis inflammation lasted more than 6 months and it has the potential to progress cirrhosis hepatocellular cancer. The disease influenced Gene X viral genotype. Mutations in are suspected having role progression. aim of this study was detect polymorphis...

BACKGROUND The HBV-X (HBX) protein is believed to contribute to the development of HCC. However, the molecular mechanisms involved in HBX- mediated hepatocarcinogenesis remain obscure. In this study, the effect of hepatitis B virus X gene and its protein product HBxAg on expression of p53 gene in Hep G2 cell line was investigated. METHODS Viral DNA extracted from HBV-positive serum and HBX ge...

conclusions functional renal impairment in diseases caused by hcv was more important than in diseases caused by hbv. the egfr was statistically lower in cirrhosis secondary to hcv than in hcv chronic hepatitis. results hbv chronic hepatitis, hcv chronic hepatitis, and cirrhosis secondary to these viruses were associated with a reduction of the gfr. the egfr was higher in patients with hbv chron...