In 1921 Oliver and Wherry described ail anaerobic, gram-negative, black pigment-producing rod isolated from human mucous membranes, tonsils, infected surgical wounds, urine, and feces. Since the black pigment formed by the organism growing on blood agar was believed to be melanin, the organism was named Bacterium melaninogenicum. This proved an unfortunate epithet, for Schwabacher, Lucas, and R...

Group A streptococci were tested for proteinase production and for the possible relationship of this production to the generation of bacteriocinlike inhibitor activity. Of 126 strains tested, 83% were positive for proteinase, and a similar distribution was found among strains isolated in association with rheumatic fever (89%) and nephritis (94%) and from uncomplicated acute infections (78%). Al...

BACKGROUND Dityrosine crosslinking in proteins is a bioinspired method of forming hydrogels. This study compares oxidative enzyme initiators for their relative crosslinking efficiency and cytocompatibility using the same phenol group and the same material platform. Four common enzyme and enzyme-like oxidative initiators were probed for resulting material properties and cell viability post-encap...

The kinetic distribution of hydrogen atoms back-exchanging from tritium-labeled proteins has been estimated from the results of interrupted flow and slow, continuousflow gel filtration. Staphylococcal nuclease exchanges almost all of it bound tritium atoms in a few hours at pH 8.1, but in the presence of calcium ions and deoxythymidine 3’,5’-diphosphate about 34 hydrogen atoms remain associated...

The heme protein found in plasma in certain diseases associated with excessive hemolysis was shown by Fairley (1) to be the product of a reaction between hematin and albumin. This component has been called methemalbumin. 111 our previous paper we have reported the results of a detailed study of this interaction, using crystallized human albumin and ferriprotoporphyrin IX (2). Each molecule of a...

Hemozoin (HZ) is an insoluble crystal formed in the food vacuole of malaria parasites. HZ has been reported to induce inflammation by directly engaging Toll-like receptor (TLR) 9, an endosomal receptor. "Synthetic" HZ (beta-hematin), typically generated from partially purified extracts of bovine hemin, is structurally identical to natural HZ. When HPLC-purified hemin was used to synthesize the ...

Abstract Background Achillea filipendulina (L.) is an important medicinal plant and Asian species of the Asteraceae family. A. that grows in Central Southwest Asia. It was chosen for study with aim screening biologically active compounds essential oil aerial parts antioxidant, antimalarial xanthine oxidase inhibitory activities its extract. Essential extracted by using Clevenger apparatus. Extr...