Objective: Clinical studies have shown that microduplications at 7q36.3, containing VIPR2, confer significant risk for schizophrenia. VIPR2 gene encodes the VPAC2 receptor for vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP). Lymphocytes from patients with these mutations exhibited higher VIPR2 gene expression and VIP responsiveness, but mechani...

Mild constitutive hyperbilirubinemia is associated with a reduced risk of cardiovascular diseases, diabetes, and cancer. Since these pathologies are associated with aging, inflammation, and oxidative stress, we investigated whether hyperbilirubinemia interferes with ROS homeostasis in cell cultures and with inflammation, senescence, and mitochondrial dysfunction in aged rats. Human embryonic ki...

BACKGROUND AND AIMS Several conditions that delay gastrointestinal transit are associated with unconjugated hyperbilirubinaemia. We hypothesised that the gastrointestinal transit time is directly related to plasma unconjugated bilirubin (UCB) concentrations, and that this relationship can be used to develop a new therapeutic strategy for severe unconjugated hyperbilirubinaemia in the Gunn rat m...

Gunn rats, which have defects in bilirubin and 4-nitrophenol UDP-glucuronyltransferases (GT), were crossed with LA Wistar rats with a defect in androsterone GT. The F1 hybrids showed normal GT activities towards androsterone, bilirubin and 4-nitrophenol, demonstrating that Gunn and LA ('low activity') Wistar rats inherit a homozygous dominant trait for androsterone GT and bilirubin GT respectiv...

GaN-based Negative Differential Resistance (NDR) diode oscillators have been studied by employing Gunn design criteria applicable to this material system. Numerical simulations were used to carry out large-signal analysis of the GaN NDR diode oscillators in order to evaluate their potential for THz signal generation. It was found that, due to the higher electron velocity and reduced time consta...

To find the optimum location of an active device i.e., Gunn diode in the Active tapered Slot-Ring Antenna (ASRA) equivalent {ABCD} matrix parameters has been used, so that the best performance in antenna characteristics is realized in terms of power radiated and power received. Microstrip tapered slotring antenna was fabricated by using a 0.787mm thick Takonic TLY-5-0310-CH/CH substrate with r...

Sir, Segni et al. (Archives, 1977, 52, 549) reported the prevention of hyperbilirubinaemia in premature infants by bucolome. The effect of bucolome on hyperbilirubinaemia in Gilbert's syndrome was well established by observation ofabout 30 cases ofthesyndrome(Yamamoto et al., 1974). However, as for the mechanism of the effect, we found that bucolome showed no induction of liver microsomal enzym...