The objective of this study was to synthesize several new pregnane derivatives and evaluate them as antiandrogens. From the commercially available 16-dehydropregnenolone acetate (7), two new steroidal compounds were synthesized: 17alpha-hydroxy-17beta-methyl-16beta-phenyl-D-homoandrosta-1,4,6-triene-3,20-dione (18) and 17alpha-acetoxy-17beta-methyl-16beta-phenyl-D-homoandrosta-1,4,6-triene-3,20...

The medial preoptic area (mPOA) of the hypothalamus contains many neurons that express estrogen receptor alpha (ER) and/or ERbeta. We examined the distribution of these receptors and assessed responses to estradiol (E2) in the adult mouse mPOA. Gonadectomized adult male and female mice were killed, and brains were processed for immunocytochemistry for ERalpha and ERbeta. More ERalpha immunoreac...

Siberian hamsters (Phodopus sungorus) exhibit changes in reproductive and immune function in response to seasonal variations in day length. Exposure to short days induces gonadal regression and inhibits testosterone secretion. In parallel, short days enhance immune function: increasing leukocyte numbers and attenuating cytokine and behavioral responses to infection. We examined whether photoper...

Transgenic (TG) mice, expressing the Simian Virus 40 T-antigen (Tag) under a 6-kb fragment of the murine inhibin alpha-subunit promoter (inh alpha p), develop gonadal tumors of granulosa/theca or Leydig cell origin. We showed previously that adrenocortical tumors develop if the TG mice are gonadectomized but never develop in intact animals. However, if functional gonadectomy was induced by GnRH...

The objective of this study was to determine the effect Apis dorsata forest honey on liver histopathological changes white rats (Rattus norvegicus) exposed physical stress. This used 24 which were divided into 4 groups. positive control group (C+) only given a stressor and distilled water orally, treatment 1 (T1) + 2g/rat/day, T2 4g/rat/day, T3 6g/rat/day. All treatments carried out within 14 d...

Small pieces of ovarian, testicular, or ovarian plus hypophyseal tissue were transplanted to the anterior eye chambers of rats, aged ~ months, which were simultaneously gonadeetomized. One year after the operations the animals were examined. The ovarian and testieular grafts had taken and had been t ransformed to tumors in a very high percentage of cases. The ovarian and testieular tumors were ...

The aim of the present study was to explore the effects of 8-OH-DPAT, 5-HT1A receptor agonist and NAN-190, 5-HT1A receptor antagonist on anxiety-related behavior in the adult gonadectomized (GDX) male rats. Moreover, another goal of this work was to investigate whether the combination of 8-OH-DPAT or NAN-190 plus testosterone propionate (TP) could affect anxiety-like behavior more than TP alone...

Abstract Dust clouds are ubiquitous in the atmospheres of hot Jupiters and affect their observable properties. The alignment dust grains resulting polarization provide a promising way to study magnetic fields exoplanets. Moreover, grain size distribution plays an important role physical chemical processes atmospheres, which rather uncertain. In this paper, we first by radiative torques (RATs). ...