NEEDLEMAN, PHILIP, DELORES J. BLEHM, ANNE B. HARKEY, EUGENE M. JOHNSON. JR. AND STANLEY LANG : The metabolic pathway in the degradation of glyceryl trinitrate. J. Pharmacol. Exp. Ther. 179: 347-353, 1971. Glyceryl trinitrate (GTN) is degraded primarily in the liver by a partial denitration process catalyzed by organic nitrate reducta.se. The supporting evidence is as follows : 1) incubation of ...

Brazil 13 14 #Corresponding author: Leonardo JM Carvalho, La Jolla Bioengineering Institute, 3535 15 General Atomics Court, Suite 210, San Diego, CA, 92121, USA, Telephone:1−858−456−7500, 16 Fax:1−858−456−7540, Email: [email protected] 17 18 AAC Accepts, published online ahead of print on 26 August 2013 Antimicrob. Agents Chemother. doi:10.1128/AAC.00488-13 Copyright © 2013, American Society f...

BACKGROUND/AIM Nitric oxide (NO) may be involved in non-adrenergic non-cholinergic (NANC) inhibitory innervation of the sphincter of Oddi (SO). The effects of topical application of glyceryl trinitrate (GTN), a NO donor, upon SO motility were examined. METHODS Nineteen patients undergoing routine SO manometry for investigation of abdominal pain were studied. After routine recording of SO moti...

Portal-systemic shunting is an important circulatory abnormality in patients with liver cirrhosis. Glyceryl trinitrate (GTN) that is normally subject to first pass elimination, may exhibit higher bioavailability in these patients. This study compares the pharmacodynamic effects of GTN after peroral and sublingual administration for noninvasive assessment of shunting. Six control subjects and 15...