The success of lentiviral vectors in curing fatal genetic and acquired diseases has opened a new era in human gene therapy. However, variability in the efficacy and safety of this therapeutic approach has been reported in human patients. Consequently, lentiviral-vector-based gene therapy is limited to incurable human diseases, with little understanding of the underlying causes of adverse effect...

Rift Valley fever (RVF) outbreaks in Kenya have increased in frequency and range to include northeastern Kenya where viruses are increasingly being isolated from known (Aedes mcintoshi) and newly-associated (Ae. ochraceus) vectors. The factors contributing to these changing outbreak patterns are unclear and the population genetic structure of key vectors and/or specific virus-vector association...

The Compact Genetic Algorithm (cGA) has a distinct characteristic that it requires almost minimal memory to store candidate solutions. The probability vector is used to generate candidate solutions. This probability vector represents a structure of the population as a probability distribution over the set of solution. It has been established that the power of cGA is comparable to the standard S...

The analysis of genomic distribution of retroviral vectors is a powerful tool to monitor 'vector-on-host' effects in gene therapy (GT) trials but also provides crucial information about 'host-on-vector' influences based on the target cell genetic and epigenetic state. We had the unique occasion to compare the insertional profile of the same therapeutic moloney murine leukemia virus (MLV) vector...

The vector borne diseases cause heavy loss to mankind and livestock industry throughout the world. Global climate changes reported to contribute to the recurrence and new epidemics of vector borne diseases. Unfortunately, the available strategies to control vector borne diseases are insufficient and public health burden of the major vector borne diseases is on increasing trend. Complete eradica...

We focused on developing efficient support vector machine based on genetic algorithm for multiclass classification from large of collection imbalanced data. And gives well sorted data. Many years ago, the scientific community is concerned about how to increase the accuracy of different classification methods, and major achievements have been made so far. Hadoop and MapReduce are used to handle ...