lactic acid bacteria which are  used  as  probiotics  have  ability to  modulate  immune responses and modify immune mechanisms. it has also been indicated that some strains of this family can affect the immune responses against solid tumors. in the present work, we proposed to study the effects of oral administration of l.cacesi ssp casei on the nk cells cytotoxicity and also production of cyt...

Centrally released oxytocin (OT) is believed to attenuate the response of the hypothalamic-pituitary-adrenal (HPA) axis to psychogenic stress. To test this hypothesis, we measured plasma corticosterone concentrations and Fos-immunoreactive protein in the paraventricular nucleus of the hypothalamus (PVN) and limbic brain areas of female wild-type and OT knockout mice that were exposed to a shake...

Ultraviolet (UV) irradiation to the skin downregulates lipid synthesis and adipokine production in subcutaneous fat. Recent evidence also suggests that UV exposure limits body weight gain obesity models. However, it is still unclear how chronic modulates energy metabolism of whole body. High fat- or normal diet-fed female C57BL/6 mice were treated with sham for 12 weeks. stimulated food intake ...

Subcutaneous immunotherapy (SCIT) is a classic form of allergen-specific that used to treat birch pollen induced allergic asthma. To investigate the underlying molecular mechanisms SCIT, we aimed profile lung samples explore changes in differential proteome before and after SCIT mice with Fresh lungs were collected from three groups female BALB/c mice: 1) control mice, 2) pollen-induced 3) SCIT...

Normally, the glomerular filtration barrier almost completely excludes circulating albumin from entering the urine. Genetic variation and both pre- and postnatal environmental factors may affect albuminuria in humans. Here we determine whether glomerular gene expression in mouse strains with naturally occurring variations in albuminuria would allow identification of proteins deregulated in rela...

High fructose intake has been associated with increased incidences of renal disease and hypertension, among other pathologies. Most fructose is cleared by the portal system and metabolized in the liver; however, systemic levels of fructose can rise with increased consumption. We tested whether there were sex differences in the renal responses to a high-fructose diet in mice. Two-month-old male ...