1. Components of the escape response of the American lobster were compared over the molt cycle. Number of tailflips, frequency, duration and distance were measured. Velocity, acceleration, force and work were computed from the above measurements, using time-lapse video-recordings of escaping lobsters. 2. Soft-shelled postmolt lobsters (stage B) traveled further, spent more time tailflipping and...

Like in the real world, the first impression a person leaves in a computer-mediated environment depends on his or her online appearance. The present study manipulates an avatar’s pupil size, eyeblink frequency, and the viewing angle to investigate whether nonverbal visual characteristics are responsible for the impression made. We assessed how participants (N = 56) evaluate these avatars in ter...

Memantine is a N-methyl-D-aspartate (NMDA) receptor antagonist approved for the treatment of moderate to severe Alzheimer's disease (AD). Environmental enrichment (EE) has shown significant beneficial effects on functional improvement in AD. In this study, we sought to determine whether combining these two distinct therapies would yield greater benefit than either drug used alone. We investigat...

Quantum effects in the noninertial Brownian motion of a particle in a double well potential are treated via a semiclassical Smoluchowski equation for the time evolution of the reduced Wigner distribution function in configuration space allowing one to evaluate the position correlation function, its characteristic relaxation times, and dynamic susceptibility using matrix continued fractions and ...

a National Superconducting Cyclotron Laboratory, Michigan State University, East Lansing, MI 48824, USA b Joint Institute for Nuclear Astrophysics, Michigan State University, East Lansing, MI 48824, USA c Department of Physics and Astronomy, Michigan State University, East Lansing, MI 48824, USA d Department of Chemistry, Michigan State University, East Lansing, MI 48824, USA e Grand Accélérate...

This paper derives from research-in-progress intending both Design Research (DR) and Design Science (DS) outputs; the former a management decision tool based in IS-Impact (Gable et al. 2008) kernel theory; the latter being methodological learnings deriving from synthesis of the literature and reflection on the DR ‘case study’ experience. The paper introduces a generic, detailed and pragmatic DS...

Seminal works in the application of design science research (DSR) in IS emphasize the importance of evaluation. However, discussion of evaluation activities and methods is limited and typically assumes an ex post perspective, in which evaluation occurs after the construction of an IS artifact. Such perspectives can assume that the evaluation is an empirical process and its methods can be select...

Intrahost human and simian immunodeficiency virus (HIV and SIV) evolution is marked by repeated viral escape from cytotoxic T-lymphocyte (CTL) response. Typically, the first such CTL escape starts around the time of peak viral load and completes within one or two weeks. Many authors have developed methods to quantify CTL escape rates, but existing methods depend on sampling at two or more timep...

When a zebrafish makes a fast escape response, Mauthner cells directly activate contralateral spinal interneurons which feed reciprocal inhibition to motorneurons on the stimulated side. Ablation of these interneurons in transgenic animals impairs escape responses, indicating their crucial role in survival.

Noise-induced escape from a metastable potential is considered on timescales preceding the formation of quasi-equilibrium within the metastable part of the potential. It is shown that the escape flux may then depend exponentially strongly, and in a complicated manner, on time and friction.