It has been reported that multiple neurological factors influence fatigability during prolonged exercise. The central fatigue hypothesis states that maximal exertion or exhaustion may directly enhance serotonergic activity via locomotor regulation or stimulation of longtermstress responses, and that the increase of serotonin(5-hydroxytryptamine, 5-HT) concentration in the brain, resulting from ...

Purpose: The aim of this study was to examine the effects of caffeine supplementation on multiple sprint running performance. Methods: Using a randomised double-blind research design, 21 physically active men ingested a gelatine capsule containing either caffeine (5 mgkg body mass -1 ) or placebo (maltodextrin) one hour before completing an indoor multiple sprint running trial (12  30 m; repe...

BACKGROUND We investigated the ergogenic effects of betaine (B) supplementation on strength and power performance. METHODS Twelve men (mean +/- SD age, 21 +/- 3 yr; mass, 79.1 +/- 10.7 kg) with a minimum of 3 months resistance training completed two 14-day experimental trials separated by a 14-day washout period, in a balanced, randomized, double-blind, repeated measures, crossover design. Pr...

This study was designed to measure whether a single dose of 120 mg pseudoephedrine ingested 120 min before exercise influences performance during 1 h of high-intensity exercise. The effects of exercise on urinary excretion of the drug were also studied. Ten healthy male cyclists were tested on two occasions, separated by at least 7 days, by using a randomly assigned, double-blind, placebo-contr...

Both an external nasal strip device (FLAIR) and furosemide significantly attenuated pulmonary hemorrhage in Thoroughbred horses following a 2-minute bout of high-speed treadmill exercise. Given the purported ergogenic effects of furosemide and the general concerns associated with drug use in racehorses, the external nasal strip is a viable alternative for the attenuation of exerciseinduced pulm...

Background The improvement in anaerobic exercise capacity associated with supplementation with creatine monohydrate (CrM) has been well established. Extracts of Russian Tarragon (RT) have been reported to produce antihyperglycemic effects [1] and influence plasma creatine levels during the ingestion of CrM [2]. Theoretically, RT ingestion may enhance creatine retention and thereby promote great...

Dietary supplements and other ergogenic aids are popular among athletes. Recent studies have shown that nutritional mixtures containing protein hydrolysates, added leucine, and high-glycaemic carbohydrates greatly augment insulin secretion compared with high-glycaemic carbohydrates only. When post-exercise hyperinsulinaemia is supported by hyperaminoacidaemia induced by protein hydrolysate and ...

Background Product specific research is necessary for determining the efficacy of dietary supplements comprised of different ingredients. Recently, the pre-workout supplement AssaultTM (MusclePharm, Denver, CO, USA) was investigated and demonstrated an ergogenic effect through improved lower body muscular endurance and agility choice reaction. However, continued product specific research is nec...