Background and Aims: Epicardial adipose tissue, exosomes, miRNAs have important activities in atherosclerosis. The purpose of this study was to establish miRNA expression profiles epicardial tissue-derived exosomes patients with coronary Methods: Biopsies tissue were obtained from without artery disease (CAD, n = 12 NCAD, 12) during elective open-heart surgeries. Tissue incubated DMEM-F12 for 2...

Through alternative splicing (AS) processes, eukaryotic genes can generate a variety of transcription isoforms that lower the expression levels normal transcripts or result in diversity genes’ activities. Then, AS plays significant role control plant development and stress tolerance. In this study, we analyzed Populus tomentosa Carr. TC1521’s episodes response to high temperatures. The samples ...

The Sequence Ontology (SO) is a structured, controlled vocabulary that provides terms and definitions for genomic annotation. Gene Regulation Ensemble Effort the Knowledge Commons (GREEKC) initiative has gathered input from many groups of researchers, including SO, (GO), gene regulation experts, with goal curating information about how expression regulated at molecular level. Here we discuss re...

Preeclampsia is a leading cause of perinatal maternal-foetal mortality and morbidity. The aim of this study is to identify the key microRNAs and genes in preeclampsia and uncover their potential functions. We downloaded the miRNA expression profile of GSE84260 and the gene expression profile of GSE73374 from the Gene Expression Omnibus database. Differentially expressed miRNAs and genes were id...

Maningat PD, Sen P, Rijnkels M, Sunehag AL, Hadsell DL, Bray M, Haymond MW. Gene expression in the human mammary epithelium during lactation: the milk fat globule transcriptome. Physiol Genomics 37: 12–22, 2009. First published November 18, 2008; doi:10.1152/physiolgenomics.90341.2008.—The molecular physiology underlying human milk production is largely unknown because of limitations in obtaini...

We have previously shown that whey protein hydrolysate (WPH) causes a greater increase in muscle protein synthesis than does a mixture of amino acids that is identical in amino acid composition. The present study was conducted to investigate the effect of WPH on gene expression. Male Sprague-Dawley rats subjected to a 2 h swimming exercise were administered either a carbohydrate-amino acid diet...

Postpartum uterine inflammation (endometritis) in the dairy cow is associated with lower fertility at both the time of infection and after the inflammation has resolved. We hypothesized that aberrant DNA methylation may be involved in the subfertility associated with uterine inflammation. The objective of this study was to characterize genome-wide DNA methylation and gene expression in the endo...