نتایج جستجو برای: endocytosis

تعداد نتایج: 14762  

Journal: :The Journal of General Physiology 1997
Jianwu Dai H. Ping Ting-Beall Michael P. Sheetz

Stimulated secretion in endocrine cells and neuronal synapses causes a rise in endocytosis rates to recover the added membrane. The endocytic process involves the mechanical deformation of the membrane to produce an invagination. Studies of osmotic swelling effects on endocytosis indicate that the increased surface tension is tightly correlated to a significant decrease of endocytosis. When rat...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2004
Veronika J Mueller Martin Wienisch Ralf B Nehring Jurgen Klingauf

To visualize clathrin redistribution during endocytosis in hippocampal boutons, we used a fusion protein of clathrin light chain with enhanced green fluorescent protein. Both high potassium and electric field stimulation lead after a stimulus-dependent delay to a transient increase of fluorescence in synapses, but a slight and transient decrease in adjacent axonal segments. We conclude that the...

2017
Kuo Liang Lisi Wei Liangyi Chen

Evoked exocytosis in excitable cells is fast and spatially confined and must be followed by coupled endocytosis to enable sustained exocytosis while maintaining the balance of the vesicle pool and the plasma membrane. Various types of exocytosis and endocytosis exist in these excitable cells, as those has been found from different types of experiments conducted in different cell types. Correlat...

Journal: :Plant signaling & behavior 2006
Susanne Salomon Silke Robatzek

Receptor-like kinases (RLKs) that function as pattern-recognition receptors (PRRs) play a key role in plant immune responses. The receptor recognizing flagellin in Arabidopsis, FLS2, is encoded by a membrane resident RLK. FLS2 is involved in preinvasive immunity against bacterial infection. Recent observations revealed that upon flagellin perception FLS2 accumulates in intracellular mobile vesi...

Journal: :Neuron 2011
Sarah J. Kotowski F. Woodward Hopf Taban Seif Antonello Bonci Mark von Zastrow

D(1) dopamine receptors are primary mediators of dopaminergic signaling in the CNS. These receptors internalize rapidly following agonist-induced activation, but the functional significance of this process is unknown. We investigated D(1) receptor endocytosis and signaling in HEK293 cells and cultured striatal neurons using real-time fluorescence imaging and cAMP biosensor technology. Agonist-i...

Journal: :The Journal of Cell Biology 2007
Tong-Wey Koh Viktor I. Korolchuk Yogesh P. Wairkar Wei Jiao Emma Evergren Hongling Pan Yi Zhou Koen J.T. Venken Oleg Shupliakov Iain M. Robinson Cahir J. O'Kane Hugo J. Bellen

Epidermal growth factor receptor pathway substrate clone 15 (Eps15) is a protein implicated in endocytosis, endosomal protein sorting, and cytoskeletal organization. Its role is, however, still unclear, because of reasons including limitations of dominant-negative experiments and apparent redundancy with other endocytic proteins. We generated Drosophila eps15-null mutants and show that Eps15 is...

2015
Chan Choo Yap Bettina Winckler

Proper cortical development depends on the orchestrated actions of a multitude of guidance receptors and adhesion molecules and their downstream signaling. The levels of these receptors on the surface and their precise locations can greatly affect guidance outcomes. Trafficking of receptors to a particular surface locale and removal by endocytosis thus feed crucially into the final guidance out...

Journal: :Developmental cell 2012
Laurence Meloty-Kapella Bhupinder Shergill Jane Kuon Elliot Botvinick Gerry Weinmaster

Notch signaling induced by cell surface ligands is critical to development and maintenance of many eukaryotic organisms. Notch and its ligands are integral membrane proteins that facilitate direct cell-cell interactions to activate Notch proteolysis and release the intracellular domain that directs Notch-specific cellular responses. Genetic studies suggest that Notch ligands require endocytosis...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
Emma L Clayton Gareth J O Evans Michael A Cousin

Bulk endocytosis in central nerve terminals is activated by strong stimulation; however, the speed at which it is initiated and for how long it persists is still a matter of debate. To resolve this issue, we performed a characterization of bulk endocytic retrieval using action potential trains of increasing intensity. Bulk endocytosis was monitored by the loading of the fluorescent dyes FM2-10 ...

Journal: :Frontiers in bioscience 2017
Yanjie Xu Jixiang Xia Suxuan Liu Sam Stein Cueto Ramon Hang Xi Luqiao Wang Xinyu Xiong Lixiao Zhang Dingwen He William Yang Xianxian Zhao Xiaoshu Cheng Xiaofeng Yang Hong Wang

Endocytosis is a cellular process mostly responsible for membrane receptor internalization. Cell membrane receptors bind to their ligands and form a complex which can be internalized. We previously proposed that F-BAR protein initiates membrane curvature and mediates endocytosis via its binding partners. However, F-BAR protein partners involved in membrane receptor endocytosis and the regulator...

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