Tibial dyschondroplasia (TD) is a poultry leg problem that affects the proximal growth plate of the tibia, preventing its transition to bone. To understand the disease-induced proteomic changes, we compared the protein extracts of cartilage from normal and TD-affected growth plates. TD was induced by feeding thiram to chickens 2 wk before tissue harvest. Proteins were extracted from whole tissu...

During longitudinal bone growth, chondrocytes within the epiphyseal plate pass through a series of well defined stages (see Brighton, 1978), characterised by changes in proliferation rate, shape and size, and synthesis and deposition of extracellular matrix components (Hunziker and Schenk, 1989). Consequently, the growth plate of the chick (Howlett, 1979) and other species can be divided into s...

Tibial dyschondroplasia (TD) is a metabolic cartilage disease of young poultry in which endochondral bone formation is disrupted leading to the retention of a non-calcified, avascular plug of cartilage in the tibial growth plate. Chicks aged 7 days were fed either a control diet or one containing thiram 100 ppm for 48 h to induce TD. Cell multiplication in the growth plate was determined therea...

Bone is composed of crystals of hydroxyapatite, a calcium phosphate, within an organic matrix composed mainly of collagen. Long bones grow longitudinally by endochondral ossification and bones thicken by intramembranous ossification. Vitamin D, after conversion to its active metabolite 1,25-dihydroxyvitamin D (1,25-D), is an important regulatory factor for the function of genes involved in calc...

Pseudopseudohypoparathyroidism (PPH) is a rare genetic disorder characterized by multiple musculoskeletal anomalies and normal serum calcium, phosphate, and parathyroid hormone levels. Although the musculoskeletal manifestations of PPH are well known, little has been reported on the management of orthopedic problems. We report a case of total knee arthroplasty (TKA) performed in a patient with ...