The analgesic effect of delta-opioid receptor (DOR) ligands in neuropathic pain is not diminished in contrast to other opioid receptor ligands, which lose their effectiveness as analgesics. In this study, we examine whether this effect is related to nerve injury-induced microglial activation. We therefore investigated the influence of minocycline-induced inhibition of microglial activation on t...

Abstract Objective To compare the effects of a pain management program and routine suctioning methods on level presence agitation in Chinese adults admitted to intensive care unit. disseminate results from implementation evidence-informed interventions for reducing during endotracheal tube (ETS) translate key finding clinical nursing practice. Methods A quasi-experimental study two-group post-t...

BACKGROUND Pregabalin, a structural analogue of gamma amino butyric acid (GABA), is shown to be effective in treatment of several types of neuropathic pain, incisional injury, and inflammatory injury. OBJECTIVES The aim of the present study is to compare the efficacy of two doses (75 mg or 150 mg) of pregabalin with the administration of a placebo for post-operative analgesia in patients unde...

This study investigates the effects of lidocaine pre-emptive treatment on neuropathic pain behavior, injury discharges of nerves, neuropeptide Y (NPY) and c-Fos expression in the cuneate nucleus (CN) after median nerve chronic constriction injury (CCI). Behavior tests demonstrated that the pre-emptive lidocaine treatment dose dependently delayed and attenuated the development of mechanical allo...

This paper examines the relative effectiveness of fixed priority non-pre-emptive scheduling (FP-NP) in a uniprocessor system, compared to an optimal workconserving non-pre-emptive algorithm; Earliest Deadline First (EDF-NP). The quantitative metric used in this comparison is the processor speedup factor, defined as the factor by which processor speed needs to increase to ensure that any taskset...

An epidemic of foot-and-mouth disease (FMD) in a FMD-free country with large exports of livestock and livestock products would result in profound economic damage. This could be reduced by rapid and efficient control of the disease spread. The objectives of this study were to estimate the economic impact of a hypothetical FMD outbreak in Denmark based on changes to the economic assumptions of th...

OBJECTIVES Pre-emptive fluconazole (fcz) anti-fungal therapy is often based upon Candida colonisation of at least 2 non-contiguous non-sterile sites. The aim of this study was to evaluate the relationship between candidaemia and prior colonisation of non-sterile sites. METHODS A retrospective observational study was performed in the intensive care unit/high dependency unit (ICU/HDU) of a Univ...

BACKGROUND Neutropenic patients with persistent fever despite antibiotic therapy are managed with empirical or pre-emptive antifungal therapy. The aim of the present study was to evaluate the current clinical use and efficacy of these two approaches in patients with high risk hematologic conditions. DESIGN AND METHODS An electronic medical record system, the "Hema e-Chart", was designed and i...