BACKGROUND Rare, recurrent genomic imbalances facilitate the association of genotype with abnormalities at the "whole body" level. However, at the cellular level, the functional consequences of recurrent genomic abnormalities and how they can be linked to the phenotype are much less investigated. METHOD AND RESULTS We report an example of a functional analysis of two genes from a new, overlap...

the aim of this paper is to improve the performance of the conventional goertzel algorithm in determining the protein codingregions in deoxyribonucleic acid (dna) sequences. first, the symbolic dna sequences are converted into numerical signals usingelectron ion interaction potential method. then by combining the modified anti-notch filter and linear predictive coding model,we proposed an effic...

g/dL), erythrocyte sedimentation rate (1 mm), and liver enzymes were within normal ranges. Abdominal ultrasound confirmed moderate ascites, and computed tomography enterography ( fig. 1 ) showed diffuse thickening of the gastric and proximal small bowel wall (arrowheads) and peritoneal fluid (arrow). Ascitic fluid analysis after an abdominal tap revealed a serum-ascites albumin gradient <1.1 g/...

Hair cells of the inner ear develop from an equivalence group marked by expression of the proneural gene Atoh1. In mouse, Atoh1 is necessary for hair cell differentiation, but its role in specifying the equivalence group (proneural function) has been questioned and little is known about its upstream activators. We have addressed these issues in zebrafish. Two zebrafish homologs, atoh1a and atoh...

An effective technique for mixer LO harmonic rejection in a SAW-less wideband receiver front-end is proposed. The proposed technique provides a tunable notch that can be placed at any frequency like mixer LO harmonics, to avoid the aliasing in baseband after mixing. An analog LC notch is used in a cascode transconductor, and it can reject one of the 3rd or 5th harmonics. T...

Four genes - deltaA, deltaB, deltaC and deltaD - coding for homologues of the Notch ligand Delta have been discovered in zebrafish (Haddon et al., 1998b). We report here the cDNA sequence and expression pattern of deltaC. Its closest relatives are deltaB and Xenopus X-Delta-2. Unlike deltaA, deltaB, and deltaD, deltaC is not expressed in the majority of nascent primary neurons; but it is strong...

This study demonstrated that the modified-live bovine viral diarrhea virus (BVDV) type 1 and 2 fractions of a multivalent vaccine protected pregnant heifers and their fetuses against virulent BVDV types 1 and 2 challenge exposures at 370 days after vaccination. All BVDV vaccinated heifers inoculated with either BVDV type 1 or 2 at approximately 62 to 94 days of gestation delivered fetuses or ca...

Mammals localize sound sources in azimuth based on two binaural cues, interaural differences in the time of arrival and level of the sounds at the ears. In contrast, the cue for elevation is based on patterns of the broadband power spectra at each ear that result from the direction-dependent acoustic filtering properties of the head and pinnae. Although the exact form of this "spectral shape" c...